Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/Gp49-HTH_37
Location 2205109..2205977 Replicon chromosome
Accession NZ_CP041803
Organism Mycobacterium tuberculosis strain SEA11278P6C4

Toxin (Protein)


Gene name higB Uniprot ID P9WJA4
Locus tag FPK06_RS10115 Protein ID WP_010886136.1
Coordinates 2205109..2205486 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0TLM0
Locus tag FPK06_RS10120 Protein ID WP_003409886.1
Coordinates 2205528..2205977 (+) Length 150 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK06_RS10065 2200898..2201350 - 453 WP_003899095.1 lipoprotein -
FPK06_RS10070 2201414..2201815 + 402 WP_003409869.1 hypothetical protein -
FPK06_RS10075 2201808..2201990 - 183 WP_003409870.1 hypothetical protein -
FPK06_RS10080 2202104..2202454 - 351 WP_003409871.1 hypothetical protein -
FPK06_RS10085 2202465..2203367 - 903 WP_003409874.1 hypothetical protein -
FPK06_RS10090 2203388..2203579 - 192 WP_003409876.1 hypothetical protein -
FPK06_RS10095 2203580..2203876 - 297 WP_003409877.1 hypothetical protein -
FPK06_RS10100 2204116..2204331 + 216 WP_003409878.1 antitoxin -
FPK06_RS10105 2204328..2204639 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
FPK06_RS10110 2204613..2205134 - 522 WP_003904745.1 hypothetical protein -
FPK06_RS10115 2205109..2205486 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB Toxin
FPK06_RS10120 2205528..2205977 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
FPK06_RS10125 2205974..2206519 + 546 WP_003409891.1 SecB-like chaperone -
FPK06_RS10130 2206408..2207022 - 615 WP_003901296.1 hypothetical protein -
FPK06_RS10135 2207071..2207367 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin -
FPK06_RS10140 2207364..2207615 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin -
FPK06_RS10145 2207602..2208096 + 495 WP_050069209.1 hypothetical protein -
FPK06_RS10150 2208256..2208663 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
FPK06_RS10155 2208667..2208939 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FPK06_RS10160 2208972..2210192 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(27-113)

Antitoxin

(44-91)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14397.77 Da        Isoelectric Point: 10.8862

>T130185 WP_010886136.1 NZ_CP041803:2205109-2205486 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI

Download         Length: 378 bp

>T130185 NZ_CP041803:2205109-2205486 [Mycobacterium tuberculosis]
GTGCCGCCCCCTGATCCAGCCGCCATGGGTACCTGGAAGTTCTTCCGGGCATCTGTGGATGGCCGGCCGGTATTCAAGAA
GGAGTTCGACAAGCTTCCTGATCAGGCCCGGGCCGCGCTGATCGTGCTAATGCAGCGGTATCTCGTCGGCGACCTCGCCG
CAGGGAGCATCAAACCGATTCGTGGCGACATTCTGGAGTTGCGATGGCATGAGGCGAACAACCACTTCCGGGTACTGTTC
TTCCGCTGGGGCCAGCATCCCGTAGCGCTGACAGCGTTCTACAAGAACCAGCAGAAGACTCCCAAGACGAAGATCGAGAC
GGCCCTGGACCGGCAGAAAATCTGGAAAAGAGCCTTCGGCGACACCCCACCGATCTGA

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16760.16 Da        Isoelectric Point: 8.0771

>AT130185 WP_003409886.1 NZ_CP041803:2205528-2205977 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA

Download         Length: 450 bp

>AT130185 NZ_CP041803:2205528-2205977 [Mycobacterium tuberculosis]
ATGAGCATTGACTTCCCTTTGGGTGACGACCTCGCCGGCTATATTGCCGAGGCGATTGCGGCTGATCCCAGCTTCAAAGG
CACTCTCGAAGACGCCGAGGAGGCACGCAGGCTGGTCGATGCGCTGATTGCGCTGCGCAAGCACTGCCAGCTGAGCCAGG
TTGAGGTTGCTAAGCGTATGGGGGTGCGCCAGCCCACCGTGAGCGGTTTCGAGAAGGAACCCAGCGACCCCAAACTGTCT
ACGCTGCAACGTTATGCCCGTGCATTGGACGCCCGGCTGCGGCTGGTGCTCGAAGTTCCCACGCTTCGCGAAGTGCCTAC
GTGGCATCGGCTCTCCTCTTATCGGGGCTCCGCACGGGACCACCAGGTCCGGGTGGGTGCAGACAAGGAAATCCTGATGC
AGACGAACTGGGCCCGCCACATTTCGGTTCGGCAGGTTGAGGTGGCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7AWK
PDB 7NBU


Antitoxin

Source ID Structure
PDB 5MTW
AlphaFold DB G0TLM0

References