Detailed information of TA system TA130022

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): unclassified/-
• Location: 2996279..2996927
• Replicon: chromosome
• Accession: NZ_CP041800
• Organism: Mycobacterium tuberculosis strain SEA12334P6C4

Toxin (Protein)

• Gene name: novel[antitoxin]
• Uniprot ID: -
• Locus tag: FPK09_RS13965
• Protein ID: WP_003903987.1
• Coordinates: 2996279..2996602 (-)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: novel[toxin]
• Uniprot ID: P9WJ10
• Locus tag: FPK09_RS13970
• Protein ID: WP_003899415.1
• Coordinates: 2996682..2996927 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPK09_RS13935	2991600..2992598	+	999	WP_003908027.1	tyrosine-type recombinase/integrase	-
FPK09_RS13940	2992612..2993076	+	465	WP_003900539.1	ParB N-terminal domain-containing protein	-
FPK09_RS13945	2993064..2993315	+	252	WP_003908028.1	hypothetical protein	-
FPK09_RS13950	2993486..2994925	-	1440	WP_031658632.1	phage major capsid protein	-
FPK09_RS13955	2994933..2995466	-	534	WP_003899412.1	HK97 family phage prohead protease	-
FPK09_RS13960	2995619..2996110	-	492	WP_003900541.1	phage terminase small subunit P27 family	-
FPK09_RS13965	2996279..2996602	-	324	WP_003903987.1	type II toxin-antitoxin system toxin	Toxin
FPK09_RS13970	2996682..2996927	-	246	WP_003899415.1	type II toxin-antitoxin system antitoxin	Antitoxin
FPK09_RS13975	2996924..2998351	-	1428	WP_003908030.1	DUF3631 domain-containing protein	-
FPK09_RS13980	2998353..2998745	-	393	WP_003899417.1	DUF2742 domain-containing protein	-
FPK09_RS13985	2998742..2999002	-	261	WP_003899418.1	helix-turn-helix domain-containing protein	-
FPK09_RS13990	2999019..2999377	-	359	Protein_2759	hypothetical protein	-
FPK09_RS13995	2999380..3000507	-	1128	WP_031674413.1	site-specific integrase	-
FPK09_RS14000	3000652..3000879	-	228	WP_003899421.1	hypothetical protein	-
FPK09_RS14005	3000876..3001265	-	390	WP_003899422.1	hypothetical protein	-
FPK09_RS14010	3001171..3001443	+	273	WP_003900544.1	hypothetical protein	-
FPK09_RS14015	3001542..3001775	+	234	WP_003413717.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_000962 Mycobacterium tuberculosis H37Rv Prophage TA000120 2970551..2980818 0.005	inside	Prophage	-	-	2991600..3000507	8907

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-117)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 12353.82 Da
• Isoelectric Point: 7.4705

>T130022 WP_003903987.1 NZ_CP041800:c2996602-2996279 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMMLGWHPYQFPDEPDSKQ

Nucleotide

• Length: 324 bp

>T130022 NZ_CP041800:c2996602-2996279 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCTGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGATGCTCGGCTGGCATCCGTATCAGTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 7697.71 Da
• Isoelectric Point: 4.8565

>AT130022 WP_003899415.1 NZ_CP041800:c2996927-2996682 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Nucleotide

• Length: 246 bp

>AT130022 NZ_CP041800:c2996927-2996682 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A806JR81