Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2996279..2996927 Replicon chromosome
Accession NZ_CP041800
Organism Mycobacterium tuberculosis strain SEA12334P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag FPK09_RS13965 Protein ID WP_003903987.1
Coordinates 2996279..2996602 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPK09_RS13970 Protein ID WP_003899415.1
Coordinates 2996682..2996927 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK09_RS13935 2991600..2992598 + 999 WP_003908027.1 tyrosine-type recombinase/integrase -
FPK09_RS13940 2992612..2993076 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPK09_RS13945 2993064..2993315 + 252 WP_003908028.1 hypothetical protein -
FPK09_RS13950 2993486..2994925 - 1440 WP_031658632.1 phage major capsid protein -
FPK09_RS13955 2994933..2995466 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPK09_RS13960 2995619..2996110 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPK09_RS13965 2996279..2996602 - 324 WP_003903987.1 type II toxin-antitoxin system toxin Toxin
FPK09_RS13970 2996682..2996927 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPK09_RS13975 2996924..2998351 - 1428 WP_003908030.1 DUF3631 domain-containing protein -
FPK09_RS13980 2998353..2998745 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPK09_RS13985 2998742..2999002 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPK09_RS13990 2999019..2999377 - 359 Protein_2759 hypothetical protein -
FPK09_RS13995 2999380..3000507 - 1128 WP_031674413.1 site-specific integrase -
FPK09_RS14000 3000652..3000879 - 228 WP_003899421.1 hypothetical protein -
FPK09_RS14005 3000876..3001265 - 390 WP_003899422.1 hypothetical protein -
FPK09_RS14010 3001171..3001443 + 273 WP_003900544.1 hypothetical protein -
FPK09_RS14015 3001542..3001775 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2991600..3000507 8907


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12353.82 Da        Isoelectric Point: 7.4705

>T130022 WP_003903987.1 NZ_CP041800:c2996602-2996279 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMMLGWHPYQFPDEPDSKQ

Download         Length: 324 bp

>T130022 NZ_CP041800:c2996602-2996279 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCTGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGATGCTCGGCTGGCATCCGTATCAGTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT130022 WP_003899415.1 NZ_CP041800:c2996927-2996682 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT130022 NZ_CP041800:c2996927-2996682 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References