130006

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/Gp49-HTH_37
Location 2216800..2217668 Replicon chromosome
Accession NZ_CP041800
Organism Mycobacterium tuberculosis strain SEA12334P6C4

Toxin (Protein)


Gene name higB Uniprot ID P9WJA4
Locus tag FPK09_RS10200 Protein ID WP_010886136.1
Coordinates 2216800..2217177 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0TLM0
Locus tag FPK09_RS10205 Protein ID WP_003409886.1
Coordinates 2217219..2217668 (+) Length 150 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK09_RS10150 2212589..2213041 - 453 WP_003899095.1 lipoprotein -
FPK09_RS10155 2213105..2213506 + 402 WP_003409869.1 hypothetical protein -
FPK09_RS10160 2213499..2213681 - 183 WP_003409870.1 hypothetical protein -
FPK09_RS10165 2213795..2214145 - 351 WP_003409871.1 hypothetical protein -
FPK09_RS10170 2214156..2215058 - 903 WP_003409874.1 hypothetical protein -
FPK09_RS10175 2215079..2215270 - 192 WP_003409876.1 hypothetical protein -
FPK09_RS10180 2215271..2215567 - 297 WP_003409877.1 hypothetical protein -
FPK09_RS10185 2215807..2216022 + 216 WP_003409878.1 antitoxin -
FPK09_RS10190 2216019..2216330 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
FPK09_RS10195 2216304..2216825 - 522 WP_003904745.1 hypothetical protein -
FPK09_RS10200 2216800..2217177 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB Toxin
FPK09_RS10205 2217219..2217668 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
FPK09_RS10210 2217665..2218210 + 546 WP_003409891.1 SecB-like chaperone -
FPK09_RS10215 2218099..2218713 - 615 WP_003901296.1 hypothetical protein -
FPK09_RS10220 2218762..2219058 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin -
FPK09_RS10225 2219055..2219306 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin -
FPK09_RS10230 2219293..2219787 + 495 WP_003899099.1 hypothetical protein -
FPK09_RS10235 2219947..2220354 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
FPK09_RS10240 2220358..2220630 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FPK09_RS10245 2220663..2221883 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(27-113)

Antitoxin

(44-91)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14397.77 Da        Isoelectric Point: 10.8862

>T130006 WP_010886136.1 NZ_CP041800:2216800-2217177 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI

Download         Length: 378 bp

>T130006 NZ_CP041800:2216800-2217177 [Mycobacterium tuberculosis]
GTGCCGCCCCCTGATCCAGCCGCCATGGGTACCTGGAAGTTCTTCCGGGCATCTGTGGATGGCCGGCCGGTATTCAAGAA
GGAGTTCGACAAGCTTCCTGATCAGGCCCGGGCCGCGCTGATCGTGCTAATGCAGCGGTATCTCGTCGGCGACCTCGCCG
CAGGGAGCATCAAACCGATTCGTGGCGACATTCTGGAGTTGCGATGGCATGAGGCGAACAACCACTTCCGGGTACTGTTC
TTCCGCTGGGGCCAGCATCCCGTAGCGCTGACAGCGTTCTACAAGAACCAGCAGAAGACTCCCAAGACGAAGATCGAGAC
GGCCCTGGACCGGCAGAAAATCTGGAAAAGAGCCTTCGGCGACACCCCACCGATCTGA

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16760.16 Da        Isoelectric Point: 8.0771

>AT130006 WP_003409886.1 NZ_CP041800:2217219-2217668 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA

Download         Length: 450 bp

>AT130006 NZ_CP041800:2217219-2217668 [Mycobacterium tuberculosis]
ATGAGCATTGACTTCCCTTTGGGTGACGACCTCGCCGGCTATATTGCCGAGGCGATTGCGGCTGATCCCAGCTTCAAAGG
CACTCTCGAAGACGCCGAGGAGGCACGCAGGCTGGTCGATGCGCTGATTGCGCTGCGCAAGCACTGCCAGCTGAGCCAGG
TTGAGGTTGCTAAGCGTATGGGGGTGCGCCAGCCCACCGTGAGCGGTTTCGAGAAGGAACCCAGCGACCCCAAACTGTCT
ACGCTGCAACGTTATGCCCGTGCATTGGACGCCCGGCTGCGGCTGGTGCTCGAAGTTCCCACGCTTCGCGAAGTGCCTAC
GTGGCATCGGCTCTCCTCTTATCGGGGCTCCGCACGGGACCACCAGGTCCGGGTGGGTGCAGACAAGGAAATCCTGATGC
AGACGAACTGGGCCCGCCACATTTCGGTTCGGCAGGTTGAGGTGGCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7AWK
PDB 7NBU


Antitoxin

Source ID Structure
AlphaFold DB G0TLM0

References