Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2749692..2750340 Replicon chromosome
Accession NZ_CP041799
Organism Mycobacterium tuberculosis strain SEA13020298P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPK10_RS12705 Protein ID WP_003899414.1
Coordinates 2749692..2750015 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPK10_RS12710 Protein ID WP_003899415.1
Coordinates 2750095..2750340 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK10_RS12675 2745015..2746013 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPK10_RS12680 2746027..2746491 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPK10_RS12685 2746479..2746730 + 252 WP_003908028.1 hypothetical protein -
FPK10_RS12690 2746901..2748340 - 1440 WP_003901443.1 phage major capsid protein -
FPK10_RS12695 2748348..2748881 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPK10_RS12700 2749034..2749525 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPK10_RS12705 2749692..2750015 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPK10_RS12710 2750095..2750340 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPK10_RS12715 2750337..2751764 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
FPK10_RS12720 2751766..2752158 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPK10_RS12725 2752155..2752415 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPK10_RS12730 2752432..2752794 - 363 WP_003900543.1 hypothetical protein -
FPK10_RS12735 2752797..2753924 - 1128 WP_003899420.1 site-specific integrase -
FPK10_RS12740 2754069..2754296 - 228 WP_003899421.1 hypothetical protein -
FPK10_RS12745 2754293..2754682 - 390 WP_003899422.1 hypothetical protein -
FPK10_RS12750 2754588..2754860 + 273 WP_003900544.1 hypothetical protein -
FPK10_RS12755 2754959..2755192 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2745015..2757011 11996


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T129951 WP_003899414.1 NZ_CP041799:c2750015-2749692 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T129951 NZ_CP041799:c2750015-2749692 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT129951 WP_003899415.1 NZ_CP041799:c2750340-2750095 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT129951 NZ_CP041799:c2750340-2750095 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References