Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2961389..2962037 Replicon chromosome
Accession NZ_CP041797
Organism Mycobacterium tuberculosis strain SEA14117P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag FPK12_RS13825 Protein ID WP_025987924.1
Coordinates 2961389..2961712 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPK12_RS13830 Protein ID WP_003899415.1
Coordinates 2961792..2962037 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK12_RS13795 2956712..2957710 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPK12_RS13800 2957724..2958188 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPK12_RS13805 2958176..2958427 + 252 WP_003908028.1 hypothetical protein -
FPK12_RS13810 2958598..2960037 - 1440 WP_193018809.1 phage major capsid protein -
FPK12_RS13815 2960045..2960578 - 534 WP_193018810.1 HK97 family phage prohead protease -
FPK12_RS13820 2960731..2961222 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPK12_RS13825 2961389..2961712 - 324 WP_025987924.1 type II toxin-antitoxin system toxin Toxin
FPK12_RS13830 2961792..2962037 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPK12_RS13835 2962034..2963461 - 1428 WP_003901445.1 DUF3631 domain-containing protein -
FPK12_RS13840 2963463..2963855 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPK12_RS13845 2963852..2964112 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPK12_RS13850 2964129..2964491 - 363 WP_003900543.1 hypothetical protein -
FPK12_RS13855 2964494..2965621 - 1128 WP_003899420.1 site-specific integrase -
FPK12_RS13860 2965766..2965993 - 228 WP_031684164.1 hypothetical protein -
FPK12_RS13865 2965990..2966379 - 390 WP_003899422.1 hypothetical protein -
FPK12_RS13870 2966285..2966557 + 273 WP_003900544.1 hypothetical protein -
FPK12_RS13875 2966656..2966889 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2956712..2965621 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12393.83 Da        Isoelectric Point: 8.6717

>T129842 WP_025987924.1 NZ_CP041797:c2961712-2961389 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRFEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T129842 NZ_CP041797:c2961712-2961389 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGTTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT129842 WP_003899415.1 NZ_CP041797:c2962037-2961792 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT129842 NZ_CP041797:c2962037-2961792 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References