Detailed information of TA system TA129781

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): unclassified/-
• Location: 2985202..2985850
• Replicon: chromosome
• Accession: NZ_CP041796
• Organism: Mycobacterium tuberculosis strain SEA14318P6C4

Toxin (Protein)

• Gene name: novel[antitoxin]
• Uniprot ID: -
• Locus tag: FPK13_RS13885
• Protein ID: WP_003903987.1
• Coordinates: 2985202..2985525 (-)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: novel[toxin]
• Uniprot ID: P9WJ10
• Locus tag: FPK13_RS13890
• Protein ID: WP_003899415.1
• Coordinates: 2985605..2985850 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPK13_RS13855	2980526..2981524	+	999	WP_003908027.1	tyrosine-type recombinase/integrase	-
FPK13_RS13860	2981538..2982002	+	465	WP_003900539.1	ParB N-terminal domain-containing protein	-
FPK13_RS13865	2981990..2982241	+	252	WP_003908028.1	hypothetical protein	-
FPK13_RS13870	2982412..2983851	-	1440	WP_003901443.1	phage major capsid protein	-
FPK13_RS13875	2983859..2984392	-	534	WP_003899412.1	HK97 family phage prohead protease	-
FPK13_RS13880	2984545..2985036	-	492	WP_003900541.1	phage terminase small subunit P27 family	-
FPK13_RS13885	2985202..2985525	-	324	WP_003903987.1	type II toxin-antitoxin system toxin	Toxin
FPK13_RS13890	2985605..2985850	-	246	WP_003899415.1	type II toxin-antitoxin system antitoxin	Antitoxin
FPK13_RS13895	2985847..2987274	-	1428	WP_003908030.1	DUF3631 domain-containing protein	-
FPK13_RS13900	2987276..2987668	-	393	WP_031699422.1	DUF2742 domain-containing protein	-
FPK13_RS13905	2987665..2987925	-	261	WP_003899418.1	helix-turn-helix domain-containing protein	-
FPK13_RS13910	2987942..2988304	-	363	WP_078442139.1	hypothetical protein	-
FPK13_RS13915	2988307..2989434	-	1128	WP_003899420.1	site-specific integrase	-
FPK13_RS13920	2989579..2989806	-	228	WP_003899421.1	hypothetical protein	-
FPK13_RS13925	2989803..2990192	-	390	WP_003899422.1	hypothetical protein	-
FPK13_RS13930	2990098..2990370	+	273	WP_003900544.1	hypothetical protein	-
FPK13_RS13935	2990469..2990702	+	234	WP_003413717.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_000962 Mycobacterium tuberculosis H37Rv Prophage TA000120 2970551..2980818 0.004	inside	Prophage	-	-	2980526..2989434	8908

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 12353.82 Da
• Isoelectric Point: 7.4705

>T129781 WP_003903987.1 NZ_CP041796:c2985525-2985202 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMMLGWHPYQFPDEPDSKQ

Nucleotide

• Length: 324 bp

>T129781 NZ_CP041796:c2985525-2985202 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCTGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGATGCTCGGCTGGCATCCGTATCAGTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 7697.71 Da
• Isoelectric Point: 4.8565

>AT129781 WP_003899415.1 NZ_CP041796:c2985850-2985605 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Nucleotide

• Length: 246 bp

>AT129781 NZ_CP041796:c2985850-2985605 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A806JR81