Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3557731..3558401 Replicon chromosome
Accession NZ_CP041791
Organism Mycobacterium tuberculosis strain SEA17020023P6C4

Toxin (Protein)


Gene name higB Uniprot ID O53332
Locus tag FPK19_RS16625 Protein ID WP_003899954.1
Coordinates 3557731..3558075 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0THF6
Locus tag FPK19_RS16630 Protein ID WP_003899955.1
Coordinates 3558072..3558401 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK19_RS16595 3552804..3553664 + 861 WP_003416628.1 alpha/beta hydrolase -
FPK19_RS16600 3553639..3554154 + 516 WP_192930999.1 nitroreductase family deazaflavin-dependent oxidoreductase -
FPK19_RS16605 3554394..3554687 + 294 WP_003416635.1 hypothetical protein -
FPK19_RS16610 3554975..3556264 + 1290 WP_003416640.1 ATP-binding protein -
FPK19_RS16615 3556611..3557045 - 435 WP_031666337.1 type II toxin-antitoxin system VapC family toxin -
FPK19_RS16620 3557048..3557500 - 453 WP_003899953.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FPK19_RS16625 3557731..3558075 + 345 WP_003899954.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FPK19_RS16630 3558072..3558401 + 330 WP_003899955.1 XRE family transcriptional regulator Antitoxin
FPK19_RS16635 3558627..3559888 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
FPK19_RS16640 3560297..3560644 + 348 WP_003899956.1 DUF2384 domain-containing protein -
FPK19_RS16645 3560641..3561261 + 621 WP_003899957.1 RES family NAD+ phosphorylase -
FPK19_RS16650 3561421..3562685 - 1265 Protein_3287 hypothetical protein -
FPK19_RS16655 3562853..3563062 + 210 WP_003416778.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-91)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12692.50 Da        Isoelectric Point: 5.6920

>T129490 WP_003899954.1 NZ_CP041791:3557731-3558075 [Mycobacterium tuberculosis]
MAVILLPQVERWFFALNRDAMASVTGAIDLLEMEGPTLGRPVVDKVNDSTFHNMKELRPAGTSIRILFAFDPARQAILLL
GGDKAGNWKRWYDNNIPIADQRSENWLASEHGGG

Download         Length: 345 bp

>T129490 NZ_CP041791:3557731-3558075 [Mycobacterium tuberculosis]
TTGGCCGTGATCCTGCTCCCGCAGGTCGAACGGTGGTTCTTCGCGCTCAACAGGGATGCGATGGCCTCGGTCACCGGCGC
CATCGACCTGCTCGAAATGGAGGGGCCGACGTTGGGCCGCCCGGTGGTCGACAAAGTGAACGACTCAACGTTTCACAACA
TGAAGGAGCTGCGCCCCGCCGGCACCAGCATCCGGATCCTGTTCGCCTTCGACCCGGCCCGGCAGGCGATCCTGCTGCTG
GGCGGTGACAAGGCAGGCAACTGGAAACGCTGGTACGACAACAACATTCCAATCGCTGACCAGCGCTCCGAGAACTGGCT
GGCGAGCGAGCACGGAGGTGGATGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11802.46 Da        Isoelectric Point: 7.4051

>AT129490 WP_003899955.1 NZ_CP041791:3558072-3558401 [Mycobacterium tuberculosis]
MTMARNWRDIRADAVAQGRVDLQRAAVAREEMRDAVLAHRLAEIRKALGHARQADVAALMGVSQARVSKLESGDLSHTEL
GTLQAYVAALGGHLRIVAEFGENTVELTA

Download         Length: 330 bp

>AT129490 NZ_CP041791:3558072-3558401 [Mycobacterium tuberculosis]
ATGACCATGGCCCGCAACTGGCGTGACATTCGCGCCGATGCCGTCGCGCAGGGCCGCGTGGATCTGCAGCGGGCCGCCGT
GGCACGCGAGGAGATGCGCGATGCCGTCCTGGCGCACCGCCTGGCCGAGATCCGCAAGGCGCTAGGCCACGCACGTCAGG
CCGACGTCGCGGCGCTGATGGGGGTCTCTCAGGCCCGTGTCTCCAAGCTGGAGAGCGGCGACCTGTCCCACACCGAACTC
GGCACCCTGCAGGCCTACGTTGCCGCCCTGGGCGGGCACCTGCGCATCGTCGCTGAGTTCGGCGAAAATACTGTCGAGCT
GACCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBK2

Antitoxin

Source ID Structure
PDB 6LTY
PDB 6LTZ
AlphaFold DB G0THF6

References