Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2972574..2973222 Replicon chromosome
Accession NZ_CP041789
Organism Mycobacterium tuberculosis strain SEA17020028P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPK21_RS13895 Protein ID WP_003899414.1
Coordinates 2972574..2972897 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPK21_RS13900 Protein ID WP_003899415.1
Coordinates 2972977..2973222 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK21_RS13865 2967897..2968895 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPK21_RS13870 2968909..2969373 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPK21_RS13875 2969361..2969612 + 252 WP_003908028.1 hypothetical protein -
FPK21_RS13880 2969783..2971222 - 1440 WP_003901443.1 phage major capsid protein -
FPK21_RS13885 2971230..2971763 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPK21_RS13890 2971916..2972407 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPK21_RS13895 2972574..2972897 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPK21_RS13900 2972977..2973222 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPK21_RS13905 2973219..2974646 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
FPK21_RS13910 2974648..2975040 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPK21_RS13915 2975037..2975297 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPK21_RS13920 2975314..2975676 - 363 WP_003900543.1 hypothetical protein -
FPK21_RS13925 2975679..2976806 - 1128 WP_003899420.1 site-specific integrase -
FPK21_RS13930 2976951..2977178 - 228 WP_003899421.1 hypothetical protein -
FPK21_RS13935 2977175..2977564 - 390 WP_003899422.1 hypothetical protein -
FPK21_RS13940 2977470..2977742 + 273 WP_003900544.1 hypothetical protein -
FPK21_RS13945 2977841..2978074 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2967897..2976806 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-116)

Antitoxin

SpoVT-AbrB domain

(5-39)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T129362 WP_003899414.1 NZ_CP041789:c2972897-2972574 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T129362 NZ_CP041789:c2972897-2972574 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT129362 WP_003899415.1 NZ_CP041789:c2973222-2972977 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT129362 NZ_CP041789:c2973222-2972977 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References