Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 216081..216696 Replicon chromosome
Accession NZ_CP041778
Organism Burkholderia sp. MS455

Toxin (Protein)


Gene name higB Uniprot ID A0A1K1Q0K5
Locus tag FPJ27_RS05470 Protein ID WP_072438178.1
Coordinates 216355..216696 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1K1Q2E5
Locus tag FPJ27_RS05465 Protein ID WP_072438177.1
Coordinates 216081..216368 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ27_RS05435 211840..212619 - 780 WP_204422248.1 5'/3'-nucleotidase SurE -
FPJ27_RS05440 212797..213105 - 309 WP_175002410.1 AzlD family protein -
FPJ27_RS05445 213098..213832 - 735 WP_204422249.1 AzlC family ABC transporter permease -
FPJ27_RS05450 213958..214416 + 459 WP_006749370.1 Lrp/AsnC family transcriptional regulator -
FPJ27_RS05455 214636..215205 + 570 WP_175960271.1 hypothetical protein -
FPJ27_RS05460 215350..216039 + 690 WP_204422250.1 YebB family permuted papain-like enzyme -
FPJ27_RS05465 216081..216368 - 288 WP_072438177.1 helix-turn-helix transcriptional regulator Antitoxin
FPJ27_RS05470 216355..216696 - 342 WP_072438178.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FPJ27_RS05475 216912..217544 - 633 WP_072438180.1 LysE family translocator -
FPJ27_RS05480 217976..219613 + 1638 WP_204423066.1 ShlB/FhaC/HecB family hemolysin secretion/activation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(21-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-87)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13054.26 Da        Isoelectric Point: 9.9708

>T129231 WP_072438178.1 NZ_CP041778:c216696-216355 [Burkholderia sp. MS455]
MRTVAYEIHFFSEQVEAGVFALPKTLTARFFALADRMEQYGPNLGEPHTRPMGDGLYEMRLKGLEGIARVFYCAAVDRRI
VMLHCFVKKTQKTPGKELETARRRLKEIRYGNL

Download         Length: 342 bp

>T129231 NZ_CP041778:c216696-216355 [Burkholderia sp. MS455]
ATGCGAACCGTCGCGTATGAAATCCATTTCTTCAGCGAGCAAGTCGAGGCAGGCGTGTTTGCGTTGCCGAAGACGCTGAC
CGCCAGGTTCTTCGCACTCGCCGACCGTATGGAGCAGTACGGCCCGAATCTGGGCGAACCTCACACCAGGCCGATGGGCG
ACGGGTTGTATGAAATGCGCTTGAAGGGCCTGGAAGGTATCGCCCGTGTGTTTTACTGTGCGGCCGTCGACCGGCGGATC
GTCATGCTTCACTGCTTCGTGAAGAAGACGCAGAAAACGCCGGGGAAAGAACTGGAAACCGCGCGCCGCCGATTGAAGGA
GATTCGATATGGCAACCTATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10407.04 Da        Isoelectric Point: 10.4476

>AT129231 WP_072438177.1 NZ_CP041778:c216368-216081 [Burkholderia sp. MS455]
MATYKALRERALSDPKVRAEYDRLNREEFALLDAMLAARRAAGLSQADVAERMGTKAPAVTRLERALATGQHSPSIETLR
KYAAACGKKLVISFA

Download         Length: 288 bp

>AT129231 NZ_CP041778:c216368-216081 [Burkholderia sp. MS455]
ATGGCAACCTATAAGGCACTGCGCGAGCGCGCATTGTCCGATCCGAAGGTACGCGCCGAATACGACCGGCTGAACCGCGA
GGAATTCGCGCTGCTCGACGCAATGCTGGCCGCCCGGCGAGCCGCCGGTCTTTCGCAGGCCGATGTGGCAGAGCGCATGG
GCACGAAGGCGCCTGCCGTCACGCGGCTCGAACGCGCGCTCGCGACAGGCCAGCACTCTCCGTCGATTGAAACACTGCGC
AAGTATGCAGCCGCGTGCGGAAAGAAACTCGTGATCTCTTTTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1K1Q0K5

Antitoxin

Source ID Structure
AlphaFold DB A0A1K1Q2E5

References