Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 7486066..7486685 Replicon chromosome
Accession NZ_CP041769
Organism Rhodococcus sp. WB9

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag FND50_RS34980 Protein ID WP_144288795.1
Coordinates 7486066..7486347 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FND50_RS34985 Protein ID WP_012690288.1
Coordinates 7486392..7486685 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FND50_RS34945 7481621..7482457 + 837 WP_144289257.1 integrase -
FND50_RS34950 7482550..7483046 - 497 Protein_6843 transposase -
FND50_RS34960 7483862..7484269 - 408 WP_144288792.1 DUF4345 domain-containing protein -
FND50_RS34965 7484367..7484951 - 585 WP_144288793.1 TetR/AcrR family transcriptional regulator -
FND50_RS36435 7485268..7485504 + 237 WP_186301205.1 hypothetical protein -
FND50_RS34975 7485621..7485887 - 267 WP_144288794.1 hypothetical protein -
FND50_RS34980 7486066..7486347 + 282 WP_144288795.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FND50_RS34985 7486392..7486685 + 294 WP_012690288.1 HigA family addiction module antidote protein Antitoxin
FND50_RS34990 7486787..7487337 - 551 Protein_6850 Hin recombinase -
FND50_RS34995 7487430..7488422 - 993 WP_144288796.1 NADP-dependent oxidoreductase -
FND50_RS35005 7488619..7489527 - 909 WP_144288797.1 SDR family oxidoreductase -
FND50_RS35010 7489635..7490348 - 714 WP_144288798.1 TetR/AcrR family transcriptional regulator -
FND50_RS35015 7490565..7491533 + 969 WP_144288799.1 enoyl-CoA hydratase/isomerase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-67)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10999.62 Da        Isoelectric Point: 10.1349

>T129204 WP_144288795.1 NZ_CP041769:7486066-7486347 [Rhodococcus sp. WB9]
VIESFADKETERVFRRQFSKKLPQDIQRIARRRLLLIEAATDVNDLRVPPGNRLEKLSGGRMGQYSVRIKDQYRICFIWR
ATAAYDVEITDYH

Download         Length: 282 bp

>T129204 NZ_CP041769:7486066-7486347 [Rhodococcus sp. WB9]
GTGATCGAATCGTTCGCCGACAAGGAGACCGAGCGAGTCTTTCGCCGGCAGTTCTCGAAGAAGCTCCCGCAGGACATTCA
GCGGATCGCGCGTCGGCGTCTGTTGTTGATCGAGGCGGCCACCGACGTCAACGACCTGCGGGTGCCCCCAGGCAACCGCC
TGGAGAAGCTCTCCGGGGGCCGGATGGGCCAGTACAGCGTCCGGATCAAAGATCAATACCGCATCTGTTTCATCTGGCGC
GCCACCGCCGCATACGACGTGGAGATCACCGACTACCACTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10775.37 Da        Isoelectric Point: 5.8064

>AT129204 WP_012690288.1 NZ_CP041769:7486392-7486685 [Rhodococcus sp. WB9]
MTTDLSPIHPGEILREDFLEPFGITQNRLATIIGVPPRRINEIVLGKRSITADTALRLAQAFGNSAQFWLNIQDRYELDL
AADKLGDTLAKITRLSA

Download         Length: 294 bp

>AT129204 NZ_CP041769:7486392-7486685 [Rhodococcus sp. WB9]
ATGACTACAGACCTGAGCCCCATTCACCCCGGCGAGATCCTCCGCGAGGACTTCCTCGAGCCTTTCGGCATCACGCAGAA
CCGCCTCGCCACGATCATCGGTGTGCCGCCCCGGCGGATCAACGAGATCGTGCTCGGAAAGCGATCGATCACCGCAGACA
CCGCACTGCGGCTGGCCCAGGCGTTCGGCAACAGCGCCCAGTTCTGGCTCAACATCCAGGACCGCTACGAGCTCGACCTC
GCGGCCGACAAGCTAGGCGACACCCTCGCCAAGATCACCCGCCTCTCGGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References