Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 275146..275773 Replicon chromosome
Accession NZ_CP041764
Organism Serratia rhizosphaerae strain KUDC3025

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FO014_RS01310 Protein ID WP_160031320.1
Coordinates 275146..275475 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FO014_RS01315 Protein ID WP_160027228.1
Coordinates 275465..275773 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FO014_RS01275 270320..270544 - 225 WP_160027217.1 hypothetical protein -
FO014_RS01280 270930..271082 - 153 WP_160027219.1 Hok/Gef family protein -
FO014_RS01285 271549..271743 - 195 WP_160027221.1 ANR family transcriptional regulator -
FO014_RS01290 271819..272400 - 582 WP_160031319.1 3'-5' exoribonuclease -
FO014_RS01295 272414..272788 - 375 WP_160027223.1 hypothetical protein -
FO014_RS01300 272894..274297 - 1404 WP_160027225.1 conserved phage C-terminal domain-containing protein -
FO014_RS01305 274300..275121 - 822 WP_160027227.1 Rha family phage regulatory protein -
FO014_RS01310 275146..275475 + 330 WP_160031320.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FO014_RS01315 275465..275773 + 309 WP_160027228.1 helix-turn-helix transcriptional regulator Antitoxin
FO014_RS01320 275832..276083 - 252 WP_160027229.1 DUF4222 domain-containing protein -
FO014_RS01325 276126..276371 - 246 WP_160027230.1 hypothetical protein -
FO014_RS01330 276394..276837 - 444 WP_160027231.1 hypothetical protein -
FO014_RS01335 276837..277046 - 210 WP_160027232.1 helix-turn-helix domain-containing protein -
FO014_RS01340 277115..277522 + 408 WP_201282905.1 helix-turn-helix domain-containing protein -
FO014_RS01345 278134..278322 + 189 WP_160027233.1 DUF1482 family protein -
FO014_RS01350 278440..279465 + 1026 WP_160027234.1 hypothetical protein -
FO014_RS01355 279468..279683 + 216 WP_160031322.1 hypothetical protein -
FO014_RS01360 279680..279928 + 249 WP_160027235.1 hypothetical protein -
FO014_RS01365 279933..280298 + 366 WP_160027236.1 YkgJ family cysteine cluster protein -
FO014_RS01370 280354..280581 + 228 WP_160027238.1 DUF4224 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 257903..281594 23691


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-97)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12915.99 Da        Isoelectric Point: 9.8234

>T129189 WP_160031320.1 NZ_CP041764:275146-275475 [Serratia rhizosphaerae]
MTYTIEYYSEDVRLEVDQLPMSMRVRYKHLIERMEIYGSNLGEPHTSPFGDRLFELRIKGSDGIARVFYCTLAGKRIVML
HSFIKKTQKTPSAERKKAETRMKEVKHDW

Download         Length: 330 bp

>T129189 NZ_CP041764:275146-275475 [Serratia rhizosphaerae]
ATGACCTACACTATTGAGTACTACAGCGAAGACGTCAGGCTTGAGGTAGACCAGCTGCCGATGAGTATGCGAGTTAGGTA
CAAGCACCTCATTGAACGCATGGAGATCTACGGTAGTAATCTTGGTGAACCGCACACCAGCCCTTTCGGTGATAGGCTTT
TTGAACTTCGAATCAAAGGCAGTGATGGTATAGCCCGTGTGTTTTACTGCACTCTCGCAGGGAAACGCATCGTTATGCTG
CACAGCTTCATCAAGAAAACGCAGAAGACACCGAGCGCTGAACGTAAGAAGGCTGAAACCAGAATGAAGGAGGTAAAGCA
TGACTGGTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11218.93 Da        Isoelectric Point: 9.7267

>AT129189 WP_160027228.1 NZ_CP041764:275465-275773 [Serratia rhizosphaerae]
MTGKRTPPTMTHNEMVAKWMEDPAFKAEYDAIEEEFALLDEMLAARKNAGLTQAQVAERMGTKATAITRMEGNLASGQSG
PSFATLKKFAHATGKKLQIRFV

Download         Length: 309 bp

>AT129189 NZ_CP041764:275465-275773 [Serratia rhizosphaerae]
ATGACTGGTAAACGCACCCCACCAACAATGACGCATAACGAAATGGTCGCAAAATGGATGGAGGATCCAGCATTTAAAGC
AGAGTACGATGCCATCGAAGAGGAGTTCGCCCTGCTTGATGAAATGCTCGCTGCGCGTAAAAATGCCGGGCTAACCCAAG
CACAGGTCGCAGAACGTATGGGAACCAAGGCCACGGCAATCACTCGCATGGAAGGCAATTTAGCCTCTGGCCAGAGCGGG
CCATCGTTCGCCACATTGAAAAAGTTTGCACATGCAACCGGCAAAAAATTGCAGATCCGTTTCGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References