Detailed information of TA system TA129091

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2898712..2898996
• Replicon: chromosome
• Accession: NZ_CP041738
• Organism: Enterococcus faecalis EnGen0107 strain B594

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: SAW_RS15335
• Protein ID: WP_002386265.1
• Coordinates: 2898868..2898996 (-)
• Length: 43 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2898712..2898919 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAW_RS15310	2894396..2895349	-	954	WP_002370087.1	siderophore ABC transporter substrate-binding protein	-
SAW_RS15315	2895388..2896143	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
SAW_RS15320	2896140..2897105	-	966	WP_002387376.1	iron chelate uptake ABC transporter family permease subunit	-
SAW_RS15325	2897102..2898049	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
SAW_RS15330	2898234..2898686	+	453	WP_002378959.1	YueI family protein	-
-	2898712..2898919	+	208	-	-	Antitoxin
SAW_RS15335	2898868..2898996	-	129	WP_002386265.1	hypothetical protein	Toxin
SAW_RS15340	2899302..2899431	-	130	Protein_2805	putative holin-like toxin	-
SAW_RS15345	2899594..2901864	-	2271	WP_002399785.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
SAW_RS15350	2902035..2902535	+	501	WP_002378961.1	cysteine hydrolase	-
SAW_RS15355	2903096..2903992	+	897	WP_002354953.1	YitT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (11-42)

Sequences

Toxin

Protein

• Length: 43 a.a.
• Molecular weight: 4742.66 Da
• Isoelectric Point: 7.0058

>T129091 WP_002386265.1 NZ_CP041738:c2898996-2898868 [Enterococcus faecalis EnGen0107]
MHFNERSIFLSIEAALELMISFAAFVALLIFGILEATKNNKK

Nucleotide

• Length: 129 bp

>T129091 NZ_CP041738:c2898996-2898868 [Enterococcus faecalis EnGen0107]
ATGCACTTTAACGAAAGGAGCATTTTTTTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGC
ACTACTGATTTTCGGTATCCTTGAAGCAACGAAAAACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 208 bp

>AT129091 NZ_CP041738:2898712-2898919 [Enterococcus faecalis EnGen0107]
TTCCATTTTAAATAGAATTATGCTATTATGAAAATGAAAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAAC
ACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTGAATCTTAACCGTTCGGCCTACGAAGCTTGTGAACGGTTAT
TTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin