129026

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2509774..2511014 Replicon chromosome
Accession NZ_CP041713
Organism Legionella geestiana strain HL-0438-4026

Toxin (Protein)


Gene name HipT Uniprot ID A0A0W0TPD4
Locus tag E3226_RS11515 Protein ID WP_028387131.1
Coordinates 2510079..2511014 (+) Length 312 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A0W0TPD9
Locus tag E3226_RS11510 Protein ID WP_028387130.1
Coordinates 2509774..2510082 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3226_RS11490 2505306..2506994 + 1689 WP_135842860.1 SGNH/GDSL hydrolase family protein -
E3226_RS11495 2507089..2508678 + 1590 WP_135842861.1 peptide chain release factor 3 -
E3226_RS11500 2508719..2509105 - 387 WP_028387128.1 hypothetical protein -
E3226_RS11505 2509550..2509777 + 228 WP_028387129.1 helix-turn-helix transcriptional regulator -
E3226_RS11510 2509774..2510082 + 309 WP_028387130.1 HipA N-terminal domain-containing protein Antitoxin
E3226_RS11515 2510079..2511014 + 936 WP_028387131.1 HipA domain-containing protein Toxin
E3226_RS11520 2511037..2512452 - 1416 WP_135842862.1 NAD(P)(+) transhydrogenase (Re/Si-specific) subunit beta -
E3226_RS11525 2512449..2512757 - 309 WP_028387133.1 NAD(P) transhydrogenase subunit alpha -
E3226_RS11530 2512750..2513874 - 1125 WP_028387134.1 NAD(P) transhydrogenase subunit alpha -
E3226_RS11535 2513962..2515344 - 1383 WP_135842863.1 HAMP domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-274)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 312 a.a.        Molecular weight: 35709.42 Da        Isoelectric Point: 8.7955

>T129026 WP_028387131.1 NZ_CP041713:2510079-2511014 [Legionella geestiana]
MKHCPVTYEAISEEEVYSQRGLHLLSPRLKTLNPLDLSADEQRQEAIARVGKMSVQGVQKKLSAKLKTKEGCFEIVDQNG
HYILKPQSDSYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSMTYFIKRFDREGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAVIEQFCTFPKIESVKLLKLTLFNFLVGNEDMHLKNFSLITRDRKICLSPAYDLLNSTIAQKNTKEELALPLKG
KKNHLTKKDLLNYFAIEKLGLNQNVIDGIVQEIRLATPVWRELIGRSFLSRPMQESYLELLEERCRRLNIL

Download         Length: 936 bp

>T129026 NZ_CP041713:2510079-2511014 [Legionella geestiana]
ATGAAACACTGTCCTGTTACCTATGAAGCGATTAGTGAGGAGGAAGTGTATTCGCAGCGTGGATTACATTTGCTGTCCCC
CCGGTTAAAAACCCTTAACCCGTTAGATTTAAGTGCCGATGAGCAGCGGCAGGAAGCAATTGCCAGGGTTGGAAAGATGT
CTGTTCAAGGTGTACAGAAGAAATTAAGTGCAAAACTCAAGACTAAAGAGGGTTGTTTTGAAATTGTCGATCAAAACGGT
CATTACATTTTAAAACCGCAAAGCGACAGTTACCCGGAATTACCGGAAAATGAAGCCATTACCATGACACTTGCCAAAAC
CATTGGCCTTGAAGTGCCGGTTCATGGTCTTGTGTATTCCAAAGACAACAGCATGACCTACTTTATAAAACGCTTTGACA
GAGAGGGTCATAACAAAAAACTGGCACTGGAAGATTTTGCACAGTTGTCGGGTGAAGACAGGCACACTAAATATAAAAGT
TCCATGGAAAAAGTGATTGCCGTCATAGAGCAGTTTTGTACATTCCCCAAAATTGAATCCGTTAAATTATTAAAGTTGAC
ACTGTTTAATTTTTTGGTCGGCAACGAAGACATGCATCTTAAAAATTTCTCCTTAATTACCCGGGACAGAAAAATTTGCC
TCTCTCCTGCATATGATTTACTGAATTCAACAATCGCTCAAAAAAATACCAAAGAAGAGCTTGCTCTGCCTTTAAAAGGT
AAAAAGAACCATCTAACAAAGAAAGATTTGCTTAACTATTTTGCCATTGAAAAATTAGGACTCAATCAAAACGTCATTGA
TGGAATCGTACAGGAAATTCGTCTCGCCACACCCGTATGGCGAGAGCTCATTGGCCGCAGTTTTTTATCTCGACCAATGC
AGGAGAGCTATCTCGAGTTGCTGGAGGAAAGATGCAGGCGATTAAACATCCTGTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11501.31 Da        Isoelectric Point: 4.5859

>AT129026 WP_028387130.1 NZ_CP041713:2509774-2510082 [Legionella geestiana]
MRTAMVAVNGINAGILEELPDGKYQFIYLDDYHGAPVSLTMPLTKKNYVFDRFPPFFEGLLPEGMMLEALLRKNKIDKND
YFSQLTAVGQDVVGAVTIEELR

Download         Length: 309 bp

>AT129026 NZ_CP041713:2509774-2510082 [Legionella geestiana]
ATGAGAACAGCGATGGTAGCAGTCAACGGAATTAACGCTGGAATATTAGAAGAACTTCCGGATGGAAAATATCAATTTAT
TTATCTCGATGATTATCATGGAGCGCCCGTTTCTCTGACTATGCCTCTGACAAAAAAGAACTATGTATTTGATCGATTTC
CGCCATTTTTTGAAGGACTGTTGCCCGAGGGCATGATGCTTGAAGCACTGCTGCGCAAAAATAAAATTGATAAAAATGAT
TATTTTAGTCAGTTAACGGCTGTTGGACAGGATGTCGTAGGTGCCGTGACTATCGAGGAACTGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0W0TPD4

Antitoxin

Source ID Structure
AlphaFold DB A0A0W0TPD9

References