Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 394910..395589 Replicon chromosome
Accession NZ_CP041695
Organism Nocardia otitidiscaviarum strain NEB252

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag FOH10_RS01555 Protein ID WP_143979340.1
Coordinates 395224..395589 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FOH10_RS01550 Protein ID WP_143979339.1
Coordinates 394910..395227 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOH10_RS01515 390175..390579 - 405 WP_143979336.1 hypothetical protein -
FOH10_RS01520 390745..390810 - 66 Protein_299 DUF397 domain-containing protein -
FOH10_RS01525 390926..392101 + 1176 WP_143979337.1 DUF3558 family protein -
FOH10_RS34640 392020..392691 - 672 WP_186000680.1 hypothetical protein -
FOH10_RS01540 392987..393937 + 951 WP_143979338.1 phosphotransferase -
FOH10_RS01545 393919..394530 - 612 WP_085996489.1 TetR/AcrR family transcriptional regulator -
FOH10_RS01550 394910..395227 - 318 WP_143979339.1 helix-turn-helix domain-containing protein Antitoxin
FOH10_RS01555 395224..395589 - 366 WP_143979340.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOH10_RS01560 395687..396463 - 777 WP_143979341.1 uracil-DNA glycosylase -
FOH10_RS01565 396493..397185 + 693 WP_143979342.1 trimeric intracellular cation channel family protein -
FOH10_RS01570 397311..397754 + 444 WP_029931205.1 GyrI-like domain-containing protein -
FOH10_RS01575 397751..398185 + 435 WP_039817131.1 effector binding domain-containing protein -
FOH10_RS01580 398439..399176 + 738 WP_143979343.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-87)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 14239.08 Da        Isoelectric Point: 4.5170

>T129020 WP_143979340.1 NZ_CP041695:c395589-395224 [Nocardia otitidiscaviarum]
VADQDWDIYVVDEVREWIEQLEGADFNRVVQAIDVLAEFGPGLGRPLADTITGSRIPNLKELRPGTVRILFVFDPWRSTV
LLVAGDKHKRWESWYREAIPLAEQRYETYLKERREELEEPR

Download         Length: 366 bp

>T129020 NZ_CP041695:c395589-395224 [Nocardia otitidiscaviarum]
GTGGCCGACCAAGACTGGGACATCTACGTAGTCGATGAGGTTCGGGAATGGATCGAGCAACTGGAAGGAGCCGACTTCAA
CCGAGTCGTTCAGGCCATCGACGTATTGGCCGAGTTCGGCCCTGGTCTCGGACGCCCGCTCGCGGATACGATCACCGGTT
CGAGGATCCCGAATCTGAAGGAGTTGCGTCCCGGCACCGTTCGAATCCTGTTCGTGTTCGATCCCTGGCGCTCGACCGTT
CTCCTGGTAGCCGGCGACAAACACAAGAGATGGGAGTCGTGGTACCGCGAGGCCATTCCATTAGCTGAGCAGCGCTACGA
GACATACTTGAAGGAACGACGAGAAGAACTGGAGGAACCGCGATGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11421.89 Da        Isoelectric Point: 7.2038

>AT129020 WP_143979339.1 NZ_CP041695:c395227-394910 [Nocardia otitidiscaviarum]
MSGYSRWRDIRAGLVDRAGGEEAVAAGREELLAEVIGQRLAEIRLSRGLTQQQIADRMGVTKGRISQIERGHIAGYELLA
RYATALGGRLQQSIHFDDGETAAIA

Download         Length: 318 bp

>AT129020 NZ_CP041695:c395227-394910 [Nocardia otitidiscaviarum]
ATGAGCGGATACTCGCGCTGGCGGGACATCCGCGCCGGGCTCGTCGATCGCGCGGGCGGCGAAGAAGCTGTCGCCGCCGG
CAGGGAAGAACTGCTGGCTGAAGTGATCGGTCAGCGGCTGGCCGAGATCCGGCTGTCCCGTGGGCTGACCCAACAGCAGA
TCGCCGACCGCATGGGAGTCACCAAGGGACGGATCTCACAAATCGAGCGCGGACATATCGCAGGCTACGAACTGCTGGCT
CGCTACGCGACCGCGCTCGGCGGCCGACTGCAACAGTCGATTCACTTCGACGACGGAGAGACAGCCGCAATCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References