Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1164787..1165289 Replicon chromosome
Accession NZ_CP041628
Organism Escherichia coli strain PE15

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag FNZ59_RS05755 Protein ID WP_000767829.1
Coordinates 1164787..1165041 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag FNZ59_RS05760 Protein ID WP_160268037.1
Coordinates 1165038..1165289 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNZ59_RS05725 1159802..1160029 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
FNZ59_RS05730 1160043..1161101 - 1059 WP_000492340.1 transport protein YeeE -
FNZ59_RS05735 1161280..1162638 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
FNZ59_RS05740 1162628..1162690 - 63 WP_010723108.1 membrane protein YoeI -
FNZ59_RS05745 1162905..1163834 - 930 WP_000803351.1 LysR family transcriptional regulator -
FNZ59_RS05750 1163880..1164704 - 825 WP_000754758.1 SDR family oxidoreductase -
FNZ59_RS05755 1164787..1165041 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
FNZ59_RS05760 1165038..1165289 - 252 WP_160268037.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
FNZ59_RS05765 1165572..1165622 + 51 WP_001364200.1 his operon leader peptide -
FNZ59_RS05770 1165768..1166667 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
FNZ59_RS05775 1166673..1167977 + 1305 WP_124326233.1 histidinol dehydrogenase -
FNZ59_RS05780 1167974..1169044 + 1071 WP_124326234.1 histidinol-phosphate transaminase -
FNZ59_RS05785 1169044..1170111 + 1068 WP_124326235.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T128878 WP_000767829.1 NZ_CP041628:c1165041-1164787 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T128878 NZ_CP041628:c1165041-1164787 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9254.53 Da        Isoelectric Point: 4.5821

>AT128878 WP_160268037.1 NZ_CP041628:c1165289-1165038 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLCSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT128878 NZ_CP041628:c1165289-1165038 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGTGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure

References