Detailed information of TA system TA128816

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-agrB/Ldr(toxin)
• Location: 1253396..1253617
• Replicon: chromosome
• Accession: NZ_CP041623
• Organism: Escherichia coli O157:H7 strain ATCC 43888

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: FNZ21_RS05905
• Protein ID: WP_001295224.1
• Coordinates: 1253396..1253503 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	agrB
Locus tag	-
Coordinates	1253552..1253617 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FNZ21_RS05880	1248649..1249401	-	753	Protein_1134	cellulose biosynthesis protein BcsQ	-
FNZ21_RS05885	1249413..1249601	-	189	WP_001063316.1	YhjR family protein	-
FNZ21_RS05890	1249874..1251445	+	1572	WP_001204920.1	cellulose biosynthesis protein BcsE	-
FNZ21_RS05895	1251442..1251633	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
FNZ21_RS05900	1251630..1253309	+	1680	WP_000191596.1	cellulose biosynthesis protein BcsG	-
FNZ21_RS05905	1253396..1253503	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	1253552..1253617	+	66	NuclAT_17	-	Antitoxin
-	1253552..1253617	+	66	NuclAT_17	-	Antitoxin
-	1253552..1253617	+	66	NuclAT_17	-	Antitoxin
-	1253552..1253617	+	66	NuclAT_17	-	Antitoxin
-	1253552..1253617	+	66	NuclAT_22	-	Antitoxin
-	1253552..1253617	+	66	NuclAT_22	-	Antitoxin
-	1253552..1253617	+	66	NuclAT_22	-	Antitoxin
-	1253552..1253617	+	66	NuclAT_22	-	Antitoxin
FNZ21_RS05915	1253979..1255250	+	1272	WP_001301684.1	amino acid permease	-
FNZ21_RS05920	1255280..1256284	-	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
FNZ21_RS05925	1256281..1257264	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
FNZ21_RS05930	1257275..1258177	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T128816 WP_001295224.1 NZ_CP041623:c1253503-1253396 [Escherichia coli O157:H7]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T128816 NZ_CP041623:c1253503-1253396 [Escherichia coli O157:H7]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT128816 NZ_CP041623:1253552-1253617 [Escherichia coli O157:H7]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin