Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 2076897..2077155 Replicon chromosome
Accession NZ_CP041620
Organism Shigella flexneri strain C32

Toxin (Protein)


Gene name hokC Uniprot ID -
Locus tag FNL95_RS11190 Protein ID WP_001181672.1
Coordinates 2076946..2077155 (+) Length 70 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 2076897..2076954 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNL95_RS11175 2072726..2073985 - 1260 WP_000494929.1 hypothetical protein -
FNL95_RS11180 2074114..2075607 - 1494 WP_001774152.1 sulfatase-like hydrolase/transferase -
FNL95_RS11185 2075627..2076388 - 762 WP_001274832.1 hypothetical protein -
- 2076897..2076954 - 58 - - Antitoxin
FNL95_RS11190 2076946..2077155 + 210 WP_001181672.1 type I toxin-antitoxin system Hok family toxin Toxin
FNL95_RS11195 2077260..2078390 - 1131 WP_001118464.1 molecular chaperone DnaJ -
FNL95_RS11200 2078479..2080395 - 1917 WP_000516135.1 molecular chaperone DnaK -
FNL95_RS11205 2080767..2081171 + 405 WP_000843687.1 DUF2541 family protein -
FNL95_RS11210 2081197..2081910 + 714 WP_001102391.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(25-66)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7757.25 Da        Isoelectric Point: 9.3680

>T128784 WP_001181672.1 NZ_CP041620:2076946-2077155 [Shigella flexneri]
MQNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 210 bp

>T128784 NZ_CP041620:2076946-2077155 [Shigella flexneri]
ATGCAGAACACATGTAGAGTGCCTCTTACTGACCGAAAGGTCAAGGAGAAGAGAGCAATGAAGCAGCATAAGGCGATGAT
TGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAAAGACCTCTGTGAGGTTCACATCC
GAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT128784 NZ_CP041620:c2076954-2076897 [Shigella flexneri]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References