128779

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 494799..495361 Replicon chromosome
Accession NZ_CP041620
Organism Shigella flexneri strain C32

Toxin (Protein)


Gene name higB Uniprot ID S1Q1V8
Locus tag FNL95_RS03315 Protein ID WP_000605675.1
Coordinates 494799..495077 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag FNL95_RS03320 Protein ID WP_000781370.1
Coordinates 495077..495361 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNL95_RS03290 490385..490816 - 432 WP_000152305.1 peroxiredoxin OsmC -
FNL95_RS03295 491161..491376 + 216 WP_000495766.1 biofilm-dependent modulation protein -
FNL95_RS03300 491478..491615 + 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
FNL95_RS03305 491772..493469 + 1698 WP_000433460.1 malate dehydrogenase -
FNL95_RS03310 493603..494613 + 1011 WP_000642412.1 alcohol dehydrogenase AdhP -
FNL95_RS03315 494799..495077 + 279 WP_000605675.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FNL95_RS03320 495077..495361 + 285 WP_000781370.1 HigA family addiction module antidote protein Antitoxin
FNL95_RS03325 495590..496243 - 654 WP_000045647.1 formate dehydrogenase-N subunit gamma -
FNL95_RS03330 496236..497120 - 885 WP_001240584.1 formate dehydrogenase N subunit beta -
FNL95_RS03335 497133..500180 - 3048 WP_011478186.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10537.16 Da        Isoelectric Point: 7.3206

>T128779 WP_000605675.1 NZ_CP041620:494799-495077 [Shigella flexneri]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAACCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T128779 NZ_CP041620:494799-495077 [Shigella flexneri]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT128779 WP_000781370.1 NZ_CP041620:495077-495361 [Shigella flexneri]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT128779 NZ_CP041620:495077-495361 [Shigella flexneri]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCAGAA
AAAACAGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1Q1V8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CUG6

References