Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 165557..166149 Replicon chromosome
Accession NZ_CP041616
Organism Ornithinimicrobium sp. H23M54

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag FNH13_RS00800 Protein ID WP_143781700.1
Coordinates 165557..165838 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FNH13_RS00805 Protein ID WP_143781701.1
Coordinates 165853..166149 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNH13_RS00770 161335..161808 - 474 WP_143784873.1 hypothetical protein -
FNH13_RS00775 161823..163334 - 1512 WP_143781695.1 amidase -
FNH13_RS00780 163392..163694 - 303 WP_143781696.1 type II toxin-antitoxin system PemK/MazF family toxin -
FNH13_RS00785 163736..164680 - 945 WP_143781697.1 cold shock domain-containing protein -
FNH13_RS00790 164756..165109 + 354 WP_143781698.1 alcohol dehydrogenase -
FNH13_RS00795 165095..165244 - 150 WP_143781699.1 toxin-antitoxin system HicB family antitoxin -
FNH13_RS00800 165557..165838 + 282 WP_143781700.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FNH13_RS00805 165853..166149 + 297 WP_143781701.1 HigA family addiction module antidote protein Antitoxin
FNH13_RS00810 166253..166516 + 264 WP_143784874.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FNH13_RS00815 166497..166775 + 279 WP_143781702.1 type II toxin-antitoxin system RelE/ParE family toxin -
FNH13_RS00820 166957..168378 - 1422 WP_143781703.1 serine hydrolase -
FNH13_RS00830 168758..169507 - 750 WP_165699959.1 class I SAM-dependent methyltransferase -
FNH13_RS00835 169980..170348 - 369 WP_114905512.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10806.34 Da        Isoelectric Point: 10.0864

>T128760 WP_143781700.1 NZ_CP041616:165557-165838 [Ornithinimicrobium sp. H23M54]
VIRSFRNTATERLWSRQRAKGVDPRIERVALRKLVMLDAAETLDDLRVPPGNRLEALKGDRAGQHSIRINQQWRICFVWT
EAGPQDVEIVDYH

Download         Length: 282 bp

>T128760 NZ_CP041616:165557-165838 [Ornithinimicrobium sp. H23M54]
GTGATCAGGTCGTTCCGGAACACTGCGACGGAGCGTCTCTGGTCTCGCCAGCGGGCTAAGGGCGTCGACCCTCGGATAGA
GAGGGTCGCCCTGCGCAAGTTGGTCATGCTGGACGCCGCCGAGACCCTGGACGACCTCAGGGTGCCGCCCGGCAACCGGC
TCGAGGCGCTCAAGGGCGACCGGGCCGGCCAGCACAGCATCAGGATCAATCAGCAGTGGCGGATCTGCTTCGTCTGGACA
GAAGCCGGTCCGCAGGACGTCGAAATCGTCGACTACCACTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11039.62 Da        Isoelectric Point: 6.9885

>AT128760 WP_143781701.1 NZ_CP041616:165853-166149 [Ornithinimicrobium sp. H23M54]
MTATITPIHPGEVLLEEFLGPLGVTQHHLAVSIGVPPRRINEIVHAKRSITADTALRLSRYFGTSDRFWINLQTRYDLET
RRDVIGADLDQIHPLQTA

Download         Length: 297 bp

>AT128760 NZ_CP041616:165853-166149 [Ornithinimicrobium sp. H23M54]
ATGACCGCGACAATCACCCCAATCCACCCCGGCGAAGTGCTGCTCGAGGAGTTCCTCGGACCCCTGGGAGTCACCCAGCA
CCACCTAGCCGTCTCCATCGGCGTGCCCCCACGGCGCATCAACGAGATCGTGCACGCCAAGCGCAGCATCACCGCCGACA
CGGCCCTGCGCCTGTCCCGCTACTTCGGGACCAGCGATCGGTTCTGGATCAACCTGCAGACCCGGTACGACCTGGAGACC
CGCAGGGACGTCATCGGAGCCGACCTGGACCAAATCCACCCTCTCCAGACTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References