128690

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 1372663..1373204 Replicon chromosome
Accession NZ_CP041511
Organism Shigella sonnei strain KCCM 41282

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag FNA55_RS06660 Protein ID WP_000615976.1
Coordinates 1372663..1372941 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag FNA55_RS06665 Protein ID WP_000729704.1
Coordinates 1372944..1373204 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNA55_RS06645 (1370245) 1370245..1370823 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
FNA55_RS06650 (1371029) 1371029..1371796 + 768 WP_000333380.1 class II glutamine amidotransferase -
FNA55_RS06655 (1371767) 1371767..1372507 - 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
FNA55_RS06660 (1372663) 1372663..1372941 - 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
FNA55_RS06665 (1372944) 1372944..1373204 - 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
FNA55_RS06670 (1373390) 1373390..1374163 + 774 WP_127148796.1 C40 family peptidase -
FNA55_RS06680 (1375213) 1375213..1375341 + 129 Protein_1281 ISAs1 family transposase -
FNA55_RS06685 (1375412) 1375412..1375909 + 498 WP_000006258.1 REP-associated tyrosine transposase RayT -
FNA55_RS06690 (1376032) 1376032..1377744 - 1713 Protein_1283 flagellar biosynthesis protein FlhA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA 1362513..1375909 13396


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T128690 WP_000615976.1 NZ_CP041511:c1372941-1372663 [Shigella sonnei]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

>T128690 NZ_CP041511:c1372941-1372663 [Shigella sonnei]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT128690 WP_000729704.1 NZ_CP041511:c1373204-1372944 [Shigella sonnei]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT128690 NZ_CP041511:c1373204-1372944 [Shigella sonnei]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCTGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6Z6

References