Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 736020..736713 Replicon chromosome
Accession NZ_CP041452
Organism Escherichia coli strain YPE3

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag FNP78_RS04245 Protein ID WP_000415584.1
Coordinates 736020..736316 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag FNP78_RS04250 Protein ID WP_000650107.1
Coordinates 736318..736713 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNP78_RS04210 731108..731422 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
FNP78_RS04215 731453..732034 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
FNP78_RS04220 732353..732685 + 333 WP_000917684.1 DUF2645 family protein -
FNP78_RS04225 732731..734080 - 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
FNP78_RS04230 734077..734736 - 660 WP_001221493.1 two-component system response regulator QseB -
FNP78_RS04235 734888..735280 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
FNP78_RS04240 735333..735815 + 483 WP_000183505.1 transcriptional regulator -
FNP78_RS04245 736020..736316 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
FNP78_RS04250 736318..736713 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
FNP78_RS04255 736846..738453 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
FNP78_RS04260 738591..740849 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T128670 WP_000415584.1 NZ_CP041452:736020-736316 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T128670 NZ_CP041452:736020-736316 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT128670 WP_000650107.1 NZ_CP041452:736318-736713 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT128670 NZ_CP041452:736318-736713 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCACAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References