Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 710567..711260 Replicon chromosome
Accession NZ_CP041422
Organism Escherichia coli strain STEC409

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag FNE86_RS03445 Protein ID WP_000415584.1
Coordinates 710567..710863 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag FNE86_RS03450 Protein ID WP_000650107.1
Coordinates 710865..711260 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNE86_RS23880 706123..706287 + 165 Protein_670 DUF2645 domain-containing protein -
FNE86_RS03415 706303..707000 - 698 Protein_671 IS1-like element IS1A family transposase -
FNE86_RS03420 707056..707232 + 177 Protein_672 DUF2645 domain-containing protein -
FNE86_RS03425 707278..708627 - 1350 WP_001618857.1 two-component system sensor histidine kinase QseC -
FNE86_RS03430 708624..709283 - 660 WP_001221493.1 two-component system response regulator QseB -
FNE86_RS03435 709435..709827 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
FNE86_RS03440 709880..710362 + 483 WP_000183505.1 transcriptional regulator -
FNE86_RS03445 710567..710863 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
FNE86_RS03450 710865..711260 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
FNE86_RS03455 711393..713000 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
FNE86_RS03460 713138..715396 + 2259 WP_001618856.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T128385 WP_000415584.1 NZ_CP041422:710567-710863 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T128385 NZ_CP041422:710567-710863 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT128385 WP_000650107.1 NZ_CP041422:710865-711260 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT128385 NZ_CP041422:710865-711260 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References