Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3936685..3936943 Replicon chromosome
Accession NZ_CP041416
Organism Escherichia coli strain STEC711

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag FNE87_RS19060 Protein ID WP_000809168.1
Coordinates 3936791..3936943 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 3936685..3936742 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNE87_RS19040 3931712..3933064 + 1353 Protein_3731 fimbria/pilus outer membrane usher protein -
FNE87_RS19045 3933077..3934035 + 959 Protein_3732 fimbrial family protein -
FNE87_RS19050 3934074..3934973 - 900 WP_001300855.1 transcriptional activator NhaR -
FNE87_RS19055 3935039..3936205 - 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
- 3936685..3936742 - 58 - - Antitoxin
FNE87_RS19060 3936791..3936943 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
FNE87_RS19065 3937047..3938177 - 1131 WP_001118464.1 molecular chaperone DnaJ -
FNE87_RS19070 3938266..3940182 - 1917 WP_000516135.1 molecular chaperone DnaK -
FNE87_RS19075 3940559..3940963 + 405 WP_000843559.1 DUF2541 family protein -
FNE87_RS19080 3940989..3941702 + 714 WP_001102383.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T128371 WP_000809168.1 NZ_CP041416:3936791-3936943 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T128371 NZ_CP041416:3936791-3936943 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT128371 NZ_CP041416:c3936742-3936685 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATAGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References