Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 1191492..1191738 Replicon chromosome
Accession NZ_CP041416
Organism Escherichia coli strain STEC711

Toxin (Protein)


Gene name hokX Uniprot ID S1PD89
Locus tag FNE87_RS05650 Protein ID WP_000956458.1
Coordinates 1191586..1191738 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokX
Locus tag -
Coordinates 1191492..1191546 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNE87_RS05635 1187002..1188801 + 1800 WP_000211954.1 NADPH-dependent assimilatory sulfite reductase flavoprotein subunit -
FNE87_RS05640 1188801..1190513 + 1713 WP_001290706.1 assimilatory sulfite reductase (NADPH) hemoprotein subunit -
FNE87_RS05645 1190587..1191321 + 735 WP_000039843.1 phosphoadenosine phosphosulfate reductase -
- 1191492..1191546 - 55 - - Antitoxin
FNE87_RS05650 1191586..1191738 + 153 WP_000956458.1 type I toxin-antitoxin system Hok family toxin Toxin
FNE87_RS05655 1191932..1194631 + 2700 WP_050864154.1 CRISPR-associated helicase/endonuclease Cas3 -
FNE87_RS05660 1194729..1196291 + 1563 WP_001084104.1 type I-E CRISPR-associated protein Cse1/CasA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5558.77 Da        Isoelectric Point: 7.6757

>T128353 WP_000956458.1 NZ_CP041416:1191586-1191738 [Escherichia coli]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Download         Length: 153 bp

>T128353 NZ_CP041416:1191586-1191738 [Escherichia coli]
ATGCTGACAAAATATGCCCTTGTGGCAATCATCGTACTGTGTTGTACAGTACTGGGATTCACGCTGATGGTAGGTGACTC
GTTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 55 bp

>AT128353 NZ_CP041416:c1191546-1191492 [Escherichia coli]
GTTTGGGTTCGAACGTAAGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TJ83

Antitoxin

Download structure file

References