Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 178602..178859 Replicon chromosome
Accession NZ_CP041416
Organism Escherichia coli strain STEC711

Toxin (Protein)


Gene name hokA Uniprot ID V0YDF1
Locus tag FNE87_RS00820 Protein ID WP_001135738.1
Coordinates 178707..178859 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokA
Locus tag -
Coordinates 178602..178656 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNE87_RS00800 173827..174822 - 996 WP_001182653.1 O-acetyltransferase WecH -
FNE87_RS00805 174997..175296 + 300 WP_000980104.1 membrane protein -
FNE87_RS00810 175391..176302 + 912 WP_001168544.1 glycine--tRNA ligase subunit alpha -
FNE87_RS00815 176312..178381 + 2070 WP_001291774.1 glycine--tRNA ligase subunit beta -
- 178602..178656 - 55 - - Antitoxin
FNE87_RS00820 178707..178859 + 153 WP_001135738.1 type I toxin-antitoxin system toxin HokA Toxin
FNE87_RS00825 179047..179259 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
FNE87_RS00830 179540..179830 - 291 WP_000455798.1 HTH-type transcriptional regulator -
FNE87_RS00835 180264..180974 + 711 WP_000190517.1 DUF3053 domain-containing protein -
FNE87_RS00840 181024..181998 - 975 WP_000805027.1 glyoxylate/hydroxypyruvate reductase GhrB -
FNE87_RS00845 182102..182761 - 660 WP_000747625.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5912.14 Da        Isoelectric Point: 7.7173

>T128346 WP_001135738.1 NZ_CP041416:178707-178859 [Escherichia coli]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQGSYELAAFLACNLKE

Download         Length: 153 bp

>T128346 NZ_CP041416:178707-178859 [Escherichia coli]
ATGCCGCAGAAATATAGATTACTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGAGATTC
ACTGTGTGAATTGCATATTAAACAGGGGAGTTATGAGCTGGCGGCATTTTTAGCCTGCAATTTAAAAGAGTAA

Antitoxin


Download         Length: 55 bp

>AT128346 NZ_CP041416:c178656-178602 [Escherichia coli]
GTTCAGGCATAGGGTAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LX93

Antitoxin

Download structure file

References