Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 369..633 Replicon plasmid p45407_2
Accession NZ_CP041394
Organism Escherichia coli strain ECOL-18-VL-LA-PA-Ryan-0026

Toxin (Protein)


Gene name pndA Uniprot ID E6BRV3
Locus tag E3Z24_RS24320 Protein ID WP_001303307.1
Coordinates 369..521 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name pndB
Locus tag -
Coordinates 571..633 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3Z24_RS24320 369..521 - 153 WP_001303307.1 Hok/Gef family protein Toxin
- 571..633 + 63 NuclAT_0 - Antitoxin
- 571..633 + 63 NuclAT_0 - Antitoxin
- 571..633 + 63 NuclAT_0 - Antitoxin
- 571..633 + 63 NuclAT_0 - Antitoxin
E3Z24_RS24325 836..1927 + 1092 WP_000426061.1 hypothetical protein -
- 1994..2054 + 61 NuclAT_2 - -
- 1994..2054 + 61 NuclAT_2 - -
- 1994..2054 + 61 NuclAT_2 - -
- 1994..2054 + 61 NuclAT_2 - -
E3Z24_RS24330 2234..3442 + 1209 WP_000121273.1 IncI1-type conjugal transfer protein TrbA -
E3Z24_RS24335 3461..4531 + 1071 WP_000151582.1 IncI1-type conjugal transfer protein TrbB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaTEM-1D / floR / ant(3'')-Ia / aac(3)-IId - 1..137828 137828


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(7-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5817.21 Da        Isoelectric Point: 8.7948

>T128301 WP_001303307.1 NZ_CP041394:c521-369 [Escherichia coli]
MPQRTFLMMLIVICVTILCFVWMVRDSLCVLRLQQGNTVLVATLAYEVKR

Download         Length: 153 bp

>T128301 NZ_CP041394:c521-369 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 63 bp

>AT128301 NZ_CP041394:571-633 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A634Q5L1

Antitoxin

Download structure file

References