Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2197450..2197996 Replicon chromosome
Accession NZ_CP041364
Organism Schleiferilactobacillus harbinensis strain NSMJ42

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag FMM01_RS10935 Protein ID WP_150392535.1
Coordinates 2197450..2197749 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag FMM01_RS10940 Protein ID WP_150392536.1
Coordinates 2197742..2197996 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FMM01_RS10915 2193696..2194247 - 552 WP_150392531.1 ECF transporter S component -
FMM01_RS10920 2194266..2195021 - 756 WP_150392532.1 SDR family NAD(P)-dependent oxidoreductase -
FMM01_RS10925 2195018..2195875 - 858 WP_190973346.1 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase -
FMM01_RS10930 2196009..2197376 + 1368 WP_150392534.1 glycoside hydrolase family 1 protein -
FMM01_RS10935 2197450..2197749 - 300 WP_150392535.1 Txe/YoeB family addiction module toxin Toxin
FMM01_RS10940 2197742..2197996 - 255 WP_150392536.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FMM01_RS10945 2198176..2199126 - 951 WP_150392537.1 endo-beta-N-acetylglucosaminidase -
FMM01_RS10950 2199146..2200741 - 1596 WP_081674945.1 extracellular solute-binding protein -
FMM01_RS10955 2200800..2201720 - 921 WP_027828261.1 carbohydrate ABC transporter permease -
FMM01_RS10960 2201736..2202695 - 960 WP_035440080.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11741.17 Da        Isoelectric Point: 6.7183

>T128230 WP_150392535.1 NZ_CP041364:c2197749-2197450 [Schleiferilactobacillus harbinensis]
MSRIKEFTPNAWQDYMWFFENDKRGLKRINKLIDNIDSADPFSGLGKPEPLRYGLGGWWSRQINHEDRLVYKVTEKRISI
LACKYHYGDAAEHTDDFDN

Download         Length: 300 bp

>T128230 NZ_CP041364:c2197749-2197450 [Schleiferilactobacillus harbinensis]
ATGAGTAGAATTAAAGAATTTACGCCCAATGCTTGGCAAGACTATATGTGGTTCTTCGAGAACGATAAGCGCGGGTTGAA
ACGGATCAACAAATTGATTGACAACATTGATTCGGCTGATCCTTTCTCTGGGTTAGGGAAACCTGAGCCGCTGCGCTATG
GGCTTGGCGGATGGTGGTCAAGGCAAATCAACCATGAGGATCGACTGGTTTACAAAGTTACGGAAAAACGCATCAGTATT
TTGGCGTGCAAATACCATTATGGTGATGCTGCCGAGCATACGGATGATTTTGATAACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9842.05 Da        Isoelectric Point: 4.6812

>AT128230 WP_150392536.1 NZ_CP041364:c2197996-2197742 [Schleiferilactobacillus harbinensis]
MEATTFSDLRKNLKAYMDKTTDDDEAVIVTRKDNKNVVLISLDNYNNMLENMHVLGNKTNRDWLEESLKQYKAGQAEERK
LMDE

Download         Length: 255 bp

>AT128230 NZ_CP041364:c2197996-2197742 [Schleiferilactobacillus harbinensis]
ATGGAAGCAACAACTTTTTCTGATTTGCGGAAGAACCTAAAGGCTTATATGGATAAGACAACGGATGACGATGAAGCAGT
GATTGTCACGCGCAAAGACAATAAAAATGTCGTCCTGATCAGCCTGGACAATTACAATAACATGCTTGAAAACATGCATG
TCCTTGGAAACAAAACTAATCGCGATTGGCTTGAGGAATCTTTGAAACAGTATAAAGCTGGTCAAGCTGAAGAACGGAAA
CTAATGGATGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References