Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2356298..2356860 Replicon chromosome
Accession NZ_CP041362
Organism Citrobacter amalonaticus strain 133355-SW-C4-Cam

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FEO47_RS11190 Protein ID WP_130098205.1
Coordinates 2356298..2356576 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FEO47_RS11195 Protein ID WP_043000693.1
Coordinates 2356576..2356860 (+) Length 95 a.a.

Genomic Context

FEO47_RS11175FEO47_RS11180FEO47_RS11185FEO47_RS11190FEO47_RS11195FEO47_RS11170FEO47_RS11200FEO47_RS11205FEO47_RS11210
Location: 2352082..2352225 (144 bp)
Type: Others
Protein ID: WP_042319017.1
Location: 2352397..2354094 (1698 bp)
Type: Others
Protein ID: WP_044257943.1
Location: 2354403..2356118 (1716 bp)
Type: Others
Protein ID: WP_142765133.1
Location: 2356298..2356576 (279 bp)
Type: Toxin
Protein ID: WP_130098205.1
Location: 2356576..2356860 (285 bp)
Type: Antitoxin
Protein ID: WP_043000693.1
Location: 2351423..2351854 (432 bp)
Type: Others
Protein ID: WP_043000697.1
Location: 2356905..2357507 (603 bp)
Type: Others
Protein ID: WP_142765134.1
Location: 2357634..2358290 (657 bp)
Type: Others
Protein ID: WP_043000691.1
Location: 2358283..2359167 (885 bp)
Type: Others
Protein ID: WP_043000690.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FEO47_RS111702351423..2351854-432WP_043000697.1peroxiredoxin OsmC-
FEO47_RS111752352082..2352225+144WP_042319017.1stationary-phase-induced ribosome-associated protein-
FEO47_RS111802352397..2354094+1698WP_044257943.1malate dehydrogenase-
FEO47_RS111852354403..2356118+1716WP_142765133.1ATP-binding cassette domain-containing protein-
FEO47_RS111902356298..2356576+279WP_130098205.1type II toxin-antitoxin system RelE/ParE family toxinToxin
FEO47_RS111952356576..2356860+285WP_043000693.1HigA family addiction module antidote proteinAntitoxin
FEO47_RS112002356905..2357507-603WP_142765134.1inorganic diphosphatase-
FEO47_RS112052357634..2358290-657WP_043000691.1formate dehydrogenase-N subunit gamma-
FEO47_RS112102358283..2359167-885WP_043000690.1formate dehydrogenase subunit beta-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10555.09 Da        Isoelectric Point: 8.9461

>T128213 WP_130098205.1 NZ_CP041362:2356298-2356576 [Citrobacter amalonaticus]
MIINFRHKGLRDLFLHGKTSGVLAKHVKRLRHRLAVIDAAGCVNDINMPGYRLHPLSGDRDGVWSISVSGNWRMTFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T128213 NZ_CP041362:2356298-2356576 [Citrobacter amalonaticus]
ATGATCATAAATTTCAGGCACAAGGGATTACGCGACCTGTTTCTTCACGGTAAAACGTCAGGCGTGCTGGCAAAGCACGT
CAAACGTTTGCGACACCGCCTCGCCGTGATTGACGCCGCAGGCTGCGTGAACGATATCAACATGCCCGGTTATCGGCTGC
ATCCTCTGAGCGGCGATCGTGATGGCGTCTGGTCAATATCGGTTTCAGGCAACTGGCGTATGACGTTCGAATTTGTCAAT
GGCGATGCGTATATTCTGGATTACGAGGATTATCACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10370.07 Da        Isoelectric Point: 10.2982

>AT128213 WP_043000693.1 NZ_CP041362:2356576-2356860 [Citrobacter amalonaticus]
MKMANHPRPGDIIQEALDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPEMWLNLQNTWSLAQAQ
KSVDVSRLRRLAVQ

Download         Length: 285 bp

>AT128213 NZ_CP041362:2356576-2356860 [Citrobacter amalonaticus]
ATGAAAATGGCGAATCATCCCCGCCCAGGGGATATCATTCAGGAAGCGCTGGACGAACTGAACGTCAGTTTGCGTGAATT
TGCCAGAGCAATGGAGATTGCGCCCTCAACCGCCAGCCGGTTACTCACGGGCAAAGCGGCACTCACCCCGGAAATGGCGA
TCAAACTCTCGGTGGTGATCGGCAGCTCCCCGGAGATGTGGCTAAATCTGCAAAATACCTGGAGTCTGGCACAAGCGCAA
AAAAGCGTGGACGTGTCCCGTCTGCGCCGTCTGGCGGTGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References