Detailed information of TA system TA128112

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2689196..2689608
• Replicon: chromosome
• Accession: NZ_CP041344
• Organism: Enterococcus faecalis strain DM01

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: FLL49_RS13665
• Protein ID: WP_016626329.1
• Coordinates: 2689453..2689608 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2689196..2689340 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FLL49_RS13650	2684266..2684448	+	183	WP_016626333.1	putative holin-like toxin	-
-	2684381..2684569	-	189	NuclAT_7	-	-
FLL49_RS13655	2684766..2684888	+	123	WP_016626332.1	putative holin-like toxin	-
-	2684821..2685047	-	227	NuclAT_5	-	-
-	2684862..2685047	-	186	NuclAT_11	-	-
-	2685029..2685078	+	50	NuclAT_13	-	-
FLL49_RS13660	2685080..2688856	-	3777	WP_016626330.1	WxL domain-containing protein	-
-	2689196..2689340	-	145	NuclAT_8	-	Antitoxin
FLL49_RS13665	2689453..2689608	+	156	WP_016626329.1	putative holin-like toxin	Toxin
FLL49_RS13670	2689717..2689881	+	165	WP_080120155.1	putative holin-like toxin	-
-	2689790..2689930	-	141	NuclAT_9	-	-
FLL49_RS13675	2690238..2694098	-	3861	WP_016626328.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-48)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5668.83 Da
• Isoelectric Point: 10.6822

>T128112 WP_016626329.1 NZ_CP041344:2689453-2689608 [Enterococcus faecalis]
MNVSAKIYERRGLLSIAEALALMISFGSFIATLIFGILKAVKEDKKNNRLL

Nucleotide

• Length: 156 bp

>T128112 NZ_CP041344:2689453-2689608 [Enterococcus faecalis]
ATGAATGTAAGTGCTAAAATCTATGAAAGGAGAGGCCTTTTGTCGATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACTTTAATCTTCGGAATCCTAAAGGCTGTTAAAGAAGACAAAAAAAATAACCGTCTACTTTGA

Antitoxin

Nucleotide

• Length: 145 bp

>AT128112 NZ_CP041344:c2689340-2689196 [Enterococcus faecalis]
TGTGCTATAATAGAAACGAAAAGAGAGCTATGCTTCCAACATAGCTCTCTAATGTAGAACCGTTTAAGACGGTGACCGTT
TTAGTTACAAAAAATAACCGTACTTGGTCAAAGTAGACGGTTATTTTTTCTTGCCATTTTTCAGC

Structures

Antitoxin