Detailed information of TA system TA128098

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2603991..2604454
• Replicon: chromosome
• Accession: NZ_CP041344
• Organism: Enterococcus faecalis strain DM01

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: S4BYM2
• Locus tag: FLL49_RS13245
• Protein ID: WP_002392696.1
• Coordinates: 2603991..2604134 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2604310..2604454 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FLL49_RS13230	2599333..2602077	+	2745	WP_141893406.1	glycoside hydrolase family 65 protein	-
FLL49_RS13235	2602092..2602742	+	651	WP_002354875.1	beta-phosphoglucomutase	-
FLL49_RS13240	2603157..2603750	+	594	WP_002385181.1	hypothetical protein	-
-	2603871..2604058	+	188	NuclAT_6	-	-
FLL49_RS13245	2603991..2604134	-	144	WP_002392696.1	putative holin-like toxin	Toxin
-	2604310..2604454	+	145	NuclAT_12	-	Antitoxin
FLL49_RS13250	2604951..2605484	+	534	WP_016626357.1	CPBP family intramembrane metalloprotease	-
FLL49_RS13255	2605538..2606509	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
FLL49_RS13260	2606684..2607121	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
FLL49_RS13265	2607254..2607808	-	555	WP_002354869.1	septum formation protein Maf	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5297.43 Da
• Isoelectric Point: 10.6867

>T128098 WP_002392696.1 NZ_CP041344:c2604134-2603991 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 144 bp

>T128098 NZ_CP041344:c2604134-2603991 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACGGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 145 bp

>AT128098 NZ_CP041344:2604310-2604454 [Enterococcus faecalis]
TTGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGCAGAGCCGTTTAAGACGGTGACCGAT
TTTGTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAACA

Structures

Toxin

• AlphaFold DB: S4BYM2

Antitoxin