Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2603871..2604134 Replicon chromosome
Accession NZ_CP041344
Organism Enterococcus faecalis strain DM01

Toxin (Protein)


Gene name txpA Uniprot ID S4BYM2
Locus tag FLL49_RS13245 Protein ID WP_002392696.1
Coordinates 2603991..2604134 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2603871..2604058 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FLL49_RS13230 2599333..2602077 + 2745 WP_141893406.1 glycoside hydrolase family 65 protein -
FLL49_RS13235 2602092..2602742 + 651 WP_002354875.1 beta-phosphoglucomutase -
FLL49_RS13240 2603157..2603750 + 594 WP_002385181.1 hypothetical protein -
- 2603871..2604058 + 188 NuclAT_6 - Antitoxin
FLL49_RS13245 2603991..2604134 - 144 WP_002392696.1 putative holin-like toxin Toxin
- 2604310..2604454 + 145 NuclAT_12 - -
FLL49_RS13250 2604951..2605484 + 534 WP_016626357.1 CPBP family intramembrane metalloprotease -
FLL49_RS13255 2605538..2606509 - 972 WP_002381060.1 ribose-phosphate diphosphokinase -
FLL49_RS13260 2606684..2607121 - 438 WP_002354871.1 peptide-methionine (R)-S-oxide reductase MsrB -
FLL49_RS13265 2607254..2607808 - 555 WP_002354869.1 septum formation protein Maf -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5297.43 Da        Isoelectric Point: 10.6867

>T128095 WP_002392696.1 NZ_CP041344:c2604134-2603991 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Download         Length: 144 bp

>T128095 NZ_CP041344:c2604134-2603991 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACGGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin


Download         Length: 188 bp

>AT128095 NZ_CP041344:2603871-2604058 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCATGT
TAATTATTTAAAAATAACCGTGCTTGGTCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGT
GCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BYM2

Antitoxin

Download structure file

References