Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1445113..1445674 Replicon chromosome
Accession NZ_CP041334
Organism Glaesserella parasuis strain HPS412

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FLK62_RS07200 Protein ID WP_075605583.1
Coordinates 1445113..1445391 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag FLK62_RS07205 Protein ID WP_005712616.1
Coordinates 1445402..1445674 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FLK62_RS07185 1440905..1442233 - 1329 WP_176443695.1 exodeoxyribonuclease VII large subunit -
FLK62_RS07190 1442347..1443609 - 1263 WP_176443696.1 serine hydroxymethyltransferase -
FLK62_RS07195 1443956..1444966 - 1011 WP_176444008.1 ornithine carbamoyltransferase -
FLK62_RS07200 1445113..1445391 + 279 WP_075605583.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FLK62_RS07205 1445402..1445674 + 273 WP_005712616.1 HigA family addiction module antidote protein Antitoxin
FLK62_RS07210 1445738..1446958 + 1221 WP_038513975.1 ATP-dependent RNA helicase RhlB -
FLK62_RS07215 1446968..1447276 + 309 Protein_1392 DUF853 family protein -
FLK62_RS07220 1447348..1448562 - 1215 WP_021114868.1 ATP-binding protein -
FLK62_RS07225 1448767..1449264 - 498 WP_149350935.1 single-stranded DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-81)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10356.73 Da        Isoelectric Point: 10.0505

>T128048 WP_075605583.1 NZ_CP041334:1445113-1445391 [Glaesserella parasuis]
MIISFKHKGLKLFFETGSTAGIQANHASKLAFQLATLNQAKSALDMNAPSWNLHQLQGNLAGHWSIKVSGNWRLTFKFQN
SHAEVVDYQDYH

Download         Length: 279 bp

>T128048 NZ_CP041334:1445113-1445391 [Glaesserella parasuis]
ATGATTATTTCATTTAAGCATAAAGGATTGAAATTATTTTTTGAAACAGGATCAACTGCAGGTATTCAAGCAAATCACGC
TAGTAAACTTGCTTTTCAATTAGCCACTCTAAACCAAGCAAAAAGTGCTTTAGATATGAATGCACCTAGCTGGAATTTAC
ATCAATTACAAGGTAATTTAGCTGGGCATTGGTCTATCAAGGTAAGTGGAAATTGGCGTTTAACTTTTAAATTTCAAAAT
AGTCACGCTGAAGTCGTGGACTATCAAGATTATCATTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10314.06 Da        Isoelectric Point: 9.8982

>AT128048 WP_005712616.1 NZ_CP041334:1445402-1445674 [Glaesserella parasuis]
MKMYNPAHPGLILREYIEGYNVTEVAKRLGVTRVTLSRILNGKAAISPEMALRLSQLLKTSPELWLGLQSQYDLWQLEQR
PSFNIQPLFA

Download         Length: 273 bp

>AT128048 NZ_CP041334:1445402-1445674 [Glaesserella parasuis]
ATGAAAATGTACAATCCAGCTCACCCAGGGCTTATTTTAAGAGAATATATTGAAGGATATAATGTCACAGAAGTGGCTAA
ACGTTTAGGTGTCACTCGTGTCACGCTCTCTCGTATTTTAAATGGCAAAGCTGCAATTTCACCTGAAATGGCTCTTAGAT
TAAGCCAATTATTAAAAACTAGCCCAGAATTATGGCTTGGTTTACAATCCCAATACGATCTTTGGCAGCTTGAACAACGC
CCAAGTTTTAATATTCAGCCGTTATTTGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References