Detailed information of TA system TA128018

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 272348..272570
• Replicon: chromosome
• Accession: NZ_CP041304
• Organism: Escherichia coli strain MSHS 133

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: FK544_RS02395
• Protein ID: WP_001295224.1
• Coordinates: 272463..272570 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	272348..272406 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FK544_RS02350	268233..269237	+	1005	WP_000107036.1	dipeptide ABC transporter ATP-binding subunit DppF	-
FK544_RS02355	269267..270538	-	1272	WP_001318103.1	amino acid permease	-
FK544_RS02365	271014..271121	+	108	WP_000170738.1	type I toxin-antitoxin system toxin Ldr family protein	-
FK544_RS02375	271497..271604	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
FK544_RS25640	271980..272087	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
-	272348..272406	-	59	-	-	Antitoxin
FK544_RS02395	272463..272570	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
FK544_RS02400	272657..274336	-	1680	WP_001562264.1	cellulose biosynthesis protein BcsG	-
FK544_RS02405	274333..274524	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
FK544_RS02410	274521..276092	-	1572	WP_141841192.1	cellulose biosynthesis protein BcsE	-
FK544_RS02415	276365..276553	+	189	WP_001063315.1	YhjR family protein	-
FK544_RS02420	276565..277317	+	753	Protein_265	cellulose biosynthesis protein BcsQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T128018 WP_001295224.1 NZ_CP041304:272463-272570 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T128018 NZ_CP041304:272463-272570 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT128018 NZ_CP041304:c272406-272348 [Escherichia coli]
TCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin