Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1811974..1812476 Replicon chromosome
Accession NZ_CP041302
Organism Escherichia coli strain MSHS 472

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag FK543_RS09725 Protein ID WP_000767829.1
Coordinates 1812222..1812476 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag FK543_RS09720 Protein ID WP_001259255.1
Coordinates 1811974..1812225 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FK543_RS09695 1807152..1808219 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
FK543_RS09700 1808219..1809289 - 1071 WP_000108980.1 histidinol-phosphate transaminase -
FK543_RS09705 1809286..1810590 - 1305 WP_072800660.1 histidinol dehydrogenase -
FK543_RS09710 1810596..1811495 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
FK543_RS09715 1811641..1811691 - 51 WP_001364200.1 his operon leader peptide -
FK543_RS09720 1811974..1812225 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
FK543_RS09725 1812222..1812476 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
FK543_RS09730 1812559..1813383 + 825 WP_000754749.1 SDR family oxidoreductase -
FK543_RS09735 1813429..1814358 + 930 WP_000803351.1 LysR family transcriptional regulator -
FK543_RS09740 1814572..1814634 + 63 WP_010723108.1 membrane protein YoeI -
FK543_RS09745 1814624..1815982 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
FK543_RS09750 1816161..1817219 + 1059 WP_141874704.1 transport protein YeeE -
FK543_RS09755 1817233..1817460 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T127982 WP_000767829.1 NZ_CP041302:1812222-1812476 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T127982 NZ_CP041302:1812222-1812476 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT127982 WP_001259255.1 NZ_CP041302:1811974-1812225 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT127982 NZ_CP041302:1811974-1812225 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References