Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 846240..846825 Replicon chromosome
Accession NZ_CP041291
Organism Acinetobacter indicus strain 94-2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FK537_RS04435 Protein ID WP_104483799.1
Coordinates 846505..846825 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FK537_RS04430 Protein ID WP_005108769.1
Coordinates 846240..846512 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FK537_RS04410 841492..842301 + 810 WP_016659852.1 cytochrome c biogenesis protein CcsA -
FK537_RS04415 842492..842908 - 417 WP_168369696.1 hypothetical protein -
FK537_RS04420 842908..844224 - 1317 WP_127801121.1 hypothetical protein -
FK537_RS04425 844410..845744 + 1335 WP_104483800.1 ISNCY family transposase -
FK537_RS04430 846240..846512 - 273 WP_005108769.1 helix-turn-helix domain-containing protein Antitoxin
FK537_RS04435 846505..846825 - 321 WP_104483799.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FK537_RS04440 847012..847209 - 198 WP_004755867.1 hypothetical protein -
FK537_RS04445 847276..847503 - 228 WP_004745640.1 hypothetical protein -
FK537_RS04450 847601..847816 - 216 WP_000071892.1 cold-shock protein -
FK537_RS04455 848271..849194 + 924 WP_104470641.1 tRNA-dihydrouridine synthase -
FK537_RS04460 849277..849681 - 405 WP_127801123.1 NUDIX domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 844410..845744 1334


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12163.03 Da        Isoelectric Point: 8.8648

>T127933 WP_104483799.1 NZ_CP041291:c846825-846505 [Acinetobacter indicus]
MLFIETSIFIKQIKELVSGEEYRQLQQDLLVQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETSILRQLVKEQFHG

Download         Length: 321 bp

>T127933 NZ_CP041291:c846825-846505 [Acinetobacter indicus]
ATGTTATTCATTGAAACCAGTATTTTTATTAAGCAAATCAAAGAGCTTGTGAGTGGTGAAGAGTATCGTCAGCTCCAGCA
AGATCTCTTGGTACAGCCTGATAAGGGCGACTTAATCAAGAATGGTGGTGGAATTCGTAAAGTACGTTGTGCTCAGGGCA
ATAAAGGCAAAAGTGGCGGTATCCGTGTGATCTATTATTGGGTTACAGAAGATGATCAGATCTTTTTCCTGGTGGCTTAT
CCAAAGTCTGTGAAAGATAATCTGACAGACAAAGAAACCTCGATTCTACGTCAATTAGTAAAGGAGCAATTTCATGGATA
A

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10050.52 Da        Isoelectric Point: 8.6797

>AT127933 WP_005108769.1 NZ_CP041291:c846512-846240 [Acinetobacter indicus]
MDNNLFDDLVASIKEAGAIKRNEIKASRVTALELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDAHPTLI

Download         Length: 273 bp

>AT127933 NZ_CP041291:c846512-846240 [Acinetobacter indicus]
ATGGATAACAACTTATTTGATGACCTGGTTGCTTCAATCAAAGAAGCTGGTGCCATAAAACGCAATGAAATAAAAGCAAG
CCGAGTCACAGCGCTTGAATTGCCAGATATTAAAGAAGTACGTGAGAAAACTGGCTTAACCCAGGCAGAGTTTGCTGCAC
GTTTGCATATCAGCGCGAGAACCCTACAAAACTGGGAACAAGGCCGTCGTTATCCGACTGGTCCTGCAGCGACTTTAATT
CGCATTCTGGATGCCCATCCAACTCTGATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References