Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1547548..1548133 Replicon chromosome
Accession NZ_CP041235
Organism Sulfurimonas sp. S2-6

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FJR45_RS08330 Protein ID WP_193150128.1
Coordinates 1547849..1548133 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FJR45_RS08325 Protein ID WP_193150127.1
Coordinates 1547548..1547838 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FJR45_RS08295 1542841..1543290 + 450 WP_193150122.1 hypothetical protein -
FJR45_RS08300 1543294..1544559 + 1266 WP_193150123.1 O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase -
FJR45_RS08305 1544611..1545717 + 1107 WP_193150124.1 homoserine O-acetyltransferase -
FJR45_RS08310 1545710..1545898 + 189 WP_151899980.1 exodeoxyribonuclease VII small subunit -
FJR45_RS08315 1545895..1546710 + 816 WP_193150125.1 carbon-nitrogen hydrolase family protein -
FJR45_RS08320 1546710..1547384 + 675 WP_193150126.1 ThiF family adenylyltransferase -
FJR45_RS08325 1547548..1547838 - 291 WP_193150127.1 HigA family addiction module antidote protein Antitoxin
FJR45_RS08330 1547849..1548133 - 285 WP_193150128.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FJR45_RS08340 1548378..1548815 - 438 WP_193150129.1 globin -
FJR45_RS08345 1548818..1551919 - 3102 WP_193150130.1 efflux RND transporter permease subunit -
FJR45_RS08350 1551929..1552207 - 279 WP_151899975.1 hypothetical protein -
FJR45_RS08355 1552204..1553130 - 927 WP_193150131.1 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-94)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11150.79 Da        Isoelectric Point: 9.7915

>T127860 WP_193150128.1 NZ_CP041235:c1548133-1547849 [Sulfurimonas sp. S2-6]
MIQSFKCKYTKQLFNGKYQKKFSQVVNNIGKRKLDMLDAAFALEDLKVSPSNHLEQLQGDLKGFYSIRINNQFRLIFKFE
NSNAYDVYIDDYHK

Download         Length: 285 bp

>T127860 NZ_CP041235:c1548133-1547849 [Sulfurimonas sp. S2-6]
ATGATTCAGTCTTTTAAATGCAAATACACAAAACAGCTTTTTAATGGTAAATACCAAAAAAAGTTTTCTCAAGTAGTTAA
TAATATCGGTAAAAGAAAATTAGATATGTTAGATGCAGCTTTTGCACTGGAAGACTTGAAAGTGTCACCATCTAATCATC
TTGAACAATTACAGGGTGATTTAAAAGGTTTTTACAGTATTAGAATTAATAACCAATTTAGACTAATTTTTAAATTTGAA
AATTCTAATGCCTATGATGTATATATAGATGATTATCATAAATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11151.02 Da        Isoelectric Point: 10.0224

>AT127860 WP_193150127.1 NZ_CP041235:c1547838-1547548 [Sulfurimonas sp. S2-6]
MKEIRPSTHPGIILKEEFALPLNLTQAKLSKDLKVGIKTLSELYNEKRGITPLMALKLSEYFGTTPQFWLNLQNAYDLYK
TYQKQKENLKEIHRAA

Download         Length: 291 bp

>AT127860 NZ_CP041235:c1547838-1547548 [Sulfurimonas sp. S2-6]
ATGAAAGAGATTAGACCAAGTACACATCCAGGTATTATATTAAAAGAAGAGTTTGCACTCCCCTTGAATTTAACGCAAGC
AAAACTCTCAAAAGACTTGAAAGTCGGCATAAAAACACTGAGTGAACTTTATAATGAAAAAAGAGGTATAACGCCACTTA
TGGCTTTAAAACTCTCTGAATATTTCGGTACAACTCCACAGTTTTGGTTAAATTTACAAAATGCTTATGATTTGTACAAA
ACATATCAAAAACAAAAAGAAAATTTAAAAGAGATACATAGAGCCGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References