Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2985191..2985839 Replicon chromosome
Accession NZ_CP041207
Organism Mycobacterium tuberculosis strain MT-0080

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FKO20_RS14540 Protein ID WP_003899414.1
Coordinates 2985191..2985514 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FKO20_RS14545 Protein ID WP_003899415.1
Coordinates 2985594..2985839 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FKO20_RS14510 2980514..2981512 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FKO20_RS14515 2981526..2981990 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FKO20_RS14520 2981978..2982229 + 252 WP_003908028.1 hypothetical protein -
FKO20_RS14525 2982400..2983839 - 1440 WP_003899411.1 phage major capsid protein -
FKO20_RS14530 2983847..2984380 - 534 WP_003899412.1 HK97 family phage prohead protease -
FKO20_RS14535 2984533..2985024 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FKO20_RS14540 2985191..2985514 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FKO20_RS14545 2985594..2985839 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FKO20_RS14550 2985836..2987263 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
FKO20_RS14555 2987265..2987657 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FKO20_RS14560 2987654..2987914 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FKO20_RS14565 2987931..2988293 - 363 WP_003900543.1 hypothetical protein -
FKO20_RS14570 2988296..2989422 - 1127 Protein_2751 site-specific integrase -
FKO20_RS14575 2989567..2989794 - 228 WP_003899421.1 hypothetical protein -
FKO20_RS14580 2989791..2990180 - 390 WP_003899422.1 hypothetical protein -
FKO20_RS14585 2990086..2990358 + 273 WP_003900544.1 hypothetical protein -
FKO20_RS14590 2990457..2990690 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2980514..2989422 8908


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T127831 WP_003899414.1 NZ_CP041207:c2985514-2985191 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T127831 NZ_CP041207:c2985514-2985191 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCTGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT127831 WP_003899415.1 NZ_CP041207:c2985839-2985594 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT127831 NZ_CP041207:c2985839-2985594 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References