Detailed information of TA system TA127763

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 4159111..4159666
• Replicon: chromosome
• Accession: NZ_CP041185
• Organism: Janthinobacterium tructae strain SNU WT1

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: FJQ89_RS18190
• Protein ID: WP_141171182.1
• Coordinates: 4159111..4159416 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: FJQ89_RS18195
• Protein ID: WP_141171183.1
• Coordinates: 4159397..4159666 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FJQ89_RS18165	4154161..4154706	+	546	WP_141171178.1	YbhB/YbcL family Raf kinase inhibitor-like protein	-
FJQ89_RS18170	4154696..4155517	+	822	WP_205704506.1	helix-turn-helix domain-containing protein	-
FJQ89_RS18175	4155585..4155923	+	339	WP_141171179.1	hypothetical protein	-
FJQ89_RS18180	4156015..4158171	+	2157	WP_141171180.1	TonB-dependent receptor	-
FJQ89_RS18185	4158352..4159020	-	669	WP_141171181.1	uracil-DNA glycosylase	-
FJQ89_RS18190	4159111..4159416	-	306	WP_141171182.1	Txe/YoeB family addiction module toxin	Toxin
FJQ89_RS18195	4159397..4159666	-	270	WP_141171183.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
FJQ89_RS18200	4159789..4160805	-	1017	WP_141171184.1	lipoyl synthase	-
FJQ89_RS18205	4160845..4161549	-	705	WP_141171185.1	lipoyl(octanoyl) transferase LipB	-
FJQ89_RS18210	4161625..4163097	-	1473	WP_141171186.1	PLP-dependent aminotransferase family protein	-
FJQ89_RS18215	4163223..4164422	+	1200	WP_141171187.1	multidrug effflux MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (17-98)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11932.59 Da
• Isoelectric Point: 7.7387

>T127763 WP_141171182.1 NZ_CP041185:c4159416-4159111 [Janthinobacterium tructae]
MKNRKTENKQQARAAVLAWTDHAWEDYLFWQENDLKILQKINDLLDECLADPFKGTGKPEPLKGDLKGVWSRRIDRQHRL
VYLPDAGCIYVAACRYYYDDK

Nucleotide

• Length: 306 bp

>T127763 NZ_CP041185:c4159416-4159111 [Janthinobacterium tructae]
ATGAAAAACCGGAAGACTGAAAACAAGCAGCAGGCGCGCGCCGCCGTGCTGGCCTGGACCGATCATGCCTGGGAAGACTA
TTTGTTCTGGCAAGAGAACGATCTGAAAATCCTGCAAAAAATCAATGACTTGCTCGATGAATGCCTGGCCGATCCATTCA
AGGGCACGGGCAAGCCGGAACCGCTGAAGGGCGATCTGAAGGGTGTCTGGTCGCGCCGCATCGACCGCCAGCACCGGCTC
GTGTATTTACCCGACGCGGGCTGTATCTACGTGGCGGCCTGCCGTTATTATTACGACGACAAATAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9769.14 Da
• Isoelectric Point: 6.7154

>AT127763 WP_141171183.1 NZ_CP041185:c4159666-4159397 [Janthinobacterium tructae]
MNILTFSEARAGLKSVMDDVCNDHTPTVITRVNGEHVVMLSLSDYNSIEETLYLLGTAKNASRLMASVAQIRAGKAQPRA
LARHEKPED

Nucleotide

• Length: 270 bp

>AT127763 NZ_CP041185:c4159666-4159397 [Janthinobacterium tructae]
ATGAATATCCTGACTTTCAGCGAGGCGCGCGCGGGCCTGAAAAGCGTGATGGACGACGTCTGCAACGACCACACGCCCAC
CGTGATCACGCGCGTGAATGGCGAACACGTGGTGATGCTGTCCTTGTCGGACTACAACAGCATCGAGGAAACCCTGTATT
TGCTGGGCACGGCAAAGAATGCCAGCCGCCTGATGGCGTCCGTGGCGCAGATCAGGGCGGGCAAGGCGCAGCCACGAGCA
TTGGCGCGGCATGAAAAACCGGAAGACTGA