Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 55577..56228 | Replicon | plasmid pCUVET596 |
| Accession | NZ_CP041149 | ||
| Organism | Acinetobacter baumannii strain CUVET-MIC596 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | S3SZA7 |
| Locus tag | FI878_RS19760 | Protein ID | WP_000269903.1 |
| Coordinates | 55577..55933 (+) | Length | 119 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | FI878_RS19765 | Protein ID | WP_001140619.1 |
| Coordinates | 55926..56228 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FI878_RS19725 | 50642..51640 | + | 999 | WP_005071537.1 | zinc-binding alcohol dehydrogenase family protein | - |
| FI878_RS19730 | 51660..51944 | + | 285 | WP_005071539.1 | antibiotic biosynthesis monooxygenase | - |
| FI878_RS19735 | 52120..52290 | + | 171 | Protein_38 | IS3 family transposase | - |
| FI878_RS19740 | 52533..52757 | + | 225 | WP_126026108.1 | hypothetical protein | - |
| FI878_RS19745 | 52779..53153 | + | 375 | WP_002125302.1 | plasmid replication DNA-binding protein | - |
| FI878_RS19750 | 53358..53747 | - | 390 | WP_114190237.1 | helix-turn-helix transcriptional regulator | - |
| FI878_RS19755 | 53856..54938 | + | 1083 | WP_114190236.1 | NADPH dehydrogenase NamA | - |
| FI878_RS19760 | 55577..55933 | + | 357 | WP_000269903.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FI878_RS19765 | 55926..56228 | + | 303 | WP_001140619.1 | XRE family transcriptional regulator | Antitoxin |
| FI878_RS19770 | 56221..56430 | + | 210 | WP_000069471.1 | hypothetical protein | - |
| FI878_RS19775 | 56540..56767 | - | 228 | WP_005071544.1 | hypothetical protein | - |
| FI878_RS19780 | 57526..58071 | - | 546 | Protein_47 | IS5 family transposase | - |
| FI878_RS19785 | 57999..58387 | - | 389 | Protein_48 | AAA family ATPase | - |
| FI878_RS19790 | 58573..58893 | + | 321 | WP_002123990.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| FI878_RS19795 | 59170..59358 | + | 189 | WP_000033474.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| FI878_RS19800 | 59345..59632 | + | 288 | WP_114189641.1 | helix-turn-helix domain-containing protein | - |
| FI878_RS19805 | 59916..60140 | - | 225 | WP_016653391.1 | hypothetical protein | - |
| FI878_RS19810 | 60161..60592 | - | 432 | WP_002033982.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..82016 | 82016 | |
| - | flank | IS/Tn | - | - | 57526..57771 | 245 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 13486.45 Da Isoelectric Point: 7.1645
>T127736 WP_000269903.1 NZ_CP041149:55577-55933 [Acinetobacter baumannii]
MWTVITTDLFNEWLAQQDQSTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYEIHLSTLGDQSNG
MWTVITTDLFNEWLAQQDQSTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYEIHLSTLGDQSNG
Download Length: 357 bp
>T127736 NZ_CP041149:55577-55933 [Acinetobacter baumannii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGCACAGCAAGATCAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGAGCTACGTGTTCAGCATCGAGGTAAACCACTGAGAGCCTTTTTCGCGTTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGCGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAAAT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGCACAGCAAGATCAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGAGCTACGTGTTCAGCATCGAGGTAAACCACTGAGAGCCTTTTTCGCGTTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGCGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAAAT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11206.01 Da Isoelectric Point: 6.7282
>AT127736 WP_001140619.1 NZ_CP041149:55926-56228 [Acinetobacter baumannii]
MAKTLQELLANRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV
MAKTLQELLANRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV
Download Length: 303 bp
>AT127736 NZ_CP041149:55926-56228 [Acinetobacter baumannii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCAGAGAGTCAAGCTCGTATTCAACAAATGGCGGATGAATT
ATTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAATTGGCTGCAACCCTTGGAATCA
AACAGCCTTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTCGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTCAATGTCTAA
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCAGAGAGTCAAGCTCGTATTCAACAAATGGCGGATGAATT
ATTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAATTGGCTGCAACCCTTGGAATCA
AACAGCCTTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTCGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTCAATGTCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|