Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 55577..56228 Replicon plasmid pCUVET596
Accession NZ_CP041149
Organism Acinetobacter baumannii strain CUVET-MIC596

Toxin (Protein)


Gene name higB Uniprot ID S3SZA7
Locus tag FI878_RS19760 Protein ID WP_000269903.1
Coordinates 55577..55933 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FI878_RS19765 Protein ID WP_001140619.1
Coordinates 55926..56228 (+) Length 101 a.a.

Genomic Context


FI878_RS19725FI878_RS19730FI878_RS19735FI878_RS19740FI878_RS19745FI878_RS19755FI878_RS19760FI878_RS19765FI878_RS19770FI878_RS19790FI878_RS19795FI878_RS19800FI878_RS19750FI878_RS19775FI878_RS19780FI878_RS19785FI878_RS19805FI878_RS19810
Location: 50642..51640 (999 bp)
Type: Others
Protein ID: WP_005071537.1
Location: 51660..51944 (285 bp)
Type: Others
Protein ID: WP_005071539.1
Location: 52120..52290 (171 bp)
Type: Others
Protein ID: Protein_38
Location: 52533..52757 (225 bp)
Type: Others
Protein ID: WP_126026108.1
Location: 52779..53153 (375 bp)
Type: Others
Protein ID: WP_002125302.1
Location: 53856..54938 (1083 bp)
Type: Others
Protein ID: WP_114190236.1
Location: 55577..55933 (357 bp)
Type: Toxin
Protein ID: WP_000269903.1
Location: 55926..56228 (303 bp)
Type: Antitoxin
Protein ID: WP_001140619.1
Location: 56221..56430 (210 bp)
Type: Others
Protein ID: WP_000069471.1
Location: 58573..58893 (321 bp)
Type: Others
Protein ID: WP_002123990.1
Location: 59170..59358 (189 bp)
Type: Others
Protein ID: WP_000033474.1
Location: 59345..59632 (288 bp)
Type: Others
Protein ID: WP_114189641.1
Location: 53358..53747 (390 bp)
Type: Others
Protein ID: WP_114190237.1
Location: 56540..56767 (228 bp)
Type: Others
Protein ID: WP_005071544.1
Location: 57526..58071 (546 bp)
Type: Others
Protein ID: Protein_47
Location: 57999..58387 (389 bp)
Type: Others
Protein ID: Protein_48
Location: 59916..60140 (225 bp)
Type: Others
Protein ID: WP_016653391.1
Location: 60161..60592 (432 bp)
Type: Others
Protein ID: WP_002033982.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FI878_RS1972550642..51640+999WP_005071537.1zinc-binding alcohol dehydrogenase family protein-
FI878_RS1973051660..51944+285WP_005071539.1antibiotic biosynthesis monooxygenase-
FI878_RS1973552120..52290+171Protein_38IS3 family transposase-
FI878_RS1974052533..52757+225WP_126026108.1hypothetical protein-
FI878_RS1974552779..53153+375WP_002125302.1plasmid replication DNA-binding protein-
FI878_RS1975053358..53747-390WP_114190237.1helix-turn-helix transcriptional regulator-
FI878_RS1975553856..54938+1083WP_114190236.1NADPH dehydrogenase NamA-
FI878_RS1976055577..55933+357WP_000269903.1type II toxin-antitoxin system RelE/ParE family toxinToxin
FI878_RS1976555926..56228+303WP_001140619.1XRE family transcriptional regulatorAntitoxin
FI878_RS1977056221..56430+210WP_000069471.1hypothetical protein-
FI878_RS1977556540..56767-228WP_005071544.1hypothetical protein-
FI878_RS1978057526..58071-546Protein_47IS5 family transposase-
FI878_RS1978557999..58387-389Protein_48AAA family ATPase-
FI878_RS1979058573..58893+321WP_002123990.1type II toxin-antitoxin system Phd/YefM family antitoxin-
FI878_RS1979559170..59358+189WP_000033474.1type II toxin-antitoxin system RelE/ParE family toxin-
FI878_RS1980059345..59632+288WP_114189641.1helix-turn-helix domain-containing protein-
FI878_RS1980559916..60140-225WP_016653391.1hypothetical protein-
FI878_RS1981060161..60592-432WP_002033982.1hypothetical protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..8201682016
-flankIS/Tn--57526..57771245


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-106)

Antitoxin

(13-89)


Sequences


Toxin        


Download         Length: 119 a.a.        Molecular weight: 13486.45 Da        Isoelectric Point: 7.1645

>T127736 WP_000269903.1 NZ_CP041149:55577-55933 [Acinetobacter baumannii]
MWTVITTDLFNEWLAQQDQSTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYEIHLSTLGDQSNG

Download         Length: 357 bp

>T127736 NZ_CP041149:55577-55933 [Acinetobacter baumannii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGCACAGCAAGATCAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGAGCTACGTGTTCAGCATCGAGGTAAACCACTGAGAGCCTTTTTCGCGTTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGCGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAAAT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11206.01 Da        Isoelectric Point: 6.7282

>AT127736 WP_001140619.1 NZ_CP041149:55926-56228 [Acinetobacter baumannii]
MAKTLQELLANRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp

>AT127736 NZ_CP041149:55926-56228 [Acinetobacter baumannii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCAGAGAGTCAAGCTCGTATTCAACAAATGGCGGATGAATT
ATTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAATTGGCTGCAACCCTTGGAATCA
AACAGCCTTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTCGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTCAATGTCTAA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A836MG83


Antitoxin

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Source
ID
Structure
No matching records found

References