Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 747683..748203 Replicon chromosome
Accession NZ_CP041146
Organism Nocardioides humi strain DCY24

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag FIV44_RS03660 Protein ID WP_141003302.1
Coordinates 747683..747943 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag FIV44_RS03665 Protein ID WP_141007718.1
Coordinates 747946..748203 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIV44_RS03630 742770..744005 + 1236 WP_141003296.1 MFS transporter -
FIV44_RS03635 743991..744614 - 624 WP_181410969.1 arsenate reductase ArsC -
FIV44_RS03640 744751..745152 + 402 WP_141003298.1 metalloregulator ArsR/SmtB family transcription factor -
FIV44_RS03645 745149..746288 + 1140 WP_141003299.1 ACR3 family arsenite efflux transporter -
FIV44_RS03650 746285..746767 + 483 WP_141003300.1 heat-shock protein HtpX -
FIV44_RS03655 746788..747246 + 459 WP_141003301.1 low molecular weight phosphatase family protein -
FIV44_RS03660 747683..747943 - 261 WP_141003302.1 Txe/YoeB family addiction module toxin Toxin
FIV44_RS03665 747946..748203 - 258 WP_141007718.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FIV44_RS03670 748985..749251 - 267 WP_141003303.1 metal-sensitive transcriptional regulator -
FIV44_RS03675 749251..749661 - 411 WP_141003304.1 DUF302 domain-containing protein -
FIV44_RS03680 749812..750114 + 303 WP_141003305.1 rhodanese-like domain-containing protein -
FIV44_RS03685 750122..751612 + 1491 WP_141003306.1 MBL fold metallo-hydrolase -
FIV44_RS03690 751614..752438 + 825 WP_141003307.1 sulfite exporter TauE/SafE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 626354..865021 238667


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-73)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10402.86 Da        Isoelectric Point: 9.7753

>T127730 WP_141003302.1 NZ_CP041146:c747943-747683 [Nocardioides humi]
MRLVWDANAWEDYLWWQTQDRKVLKRINLLIQDVVRNGNEGIGKPEPLKHDFAGYWSRRITDEHRLVYKVTSTEVRIAAC
RYHYGR

Download         Length: 261 bp

>T127730 NZ_CP041146:c747943-747683 [Nocardioides humi]
ATGCGGCTGGTCTGGGACGCCAATGCCTGGGAGGACTACCTGTGGTGGCAGACCCAGGACCGCAAGGTCCTGAAGCGCAT
CAACCTGCTCATCCAAGACGTCGTGCGCAACGGCAACGAAGGCATCGGCAAGCCCGAGCCGCTCAAGCACGACTTCGCCG
GCTACTGGTCACGGCGGATCACCGACGAACACCGGCTGGTCTACAAGGTCACCAGCACTGAAGTCCGCATCGCCGCCTGC
CGCTACCACTACGGCCGCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9561.64 Da        Isoelectric Point: 4.4056

>AT127730 WP_141007718.1 NZ_CP041146:c748203-747946 [Nocardioides humi]
VKTLSYTESRARYAQVLDDVVNDREEVVITRAGHPSVVIVSLEDFESLRETAYLMRSPANARRLLDAMERLEANAGESHD
LLDAD

Download         Length: 258 bp

>AT127730 NZ_CP041146:c748203-747946 [Nocardioides humi]
GTGAAGACGCTGAGCTACACCGAGTCCCGGGCCCGTTATGCCCAGGTGCTCGATGACGTGGTGAACGACCGAGAGGAAGT
CGTGATCACCCGAGCCGGTCACCCCTCGGTGGTGATCGTGTCGTTGGAGGACTTCGAGTCCCTGCGCGAAACCGCCTACC
TGATGCGCTCACCCGCCAACGCTCGTCGCCTGCTCGATGCCATGGAGCGTCTGGAGGCCAACGCAGGGGAGAGCCACGAC
CTCCTCGACGCCGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References