Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 3510330..3510987 Replicon chromosome
Accession NZ_CP041130
Organism Serratia marcescens strain WVU-007

Toxin (Protein)


Gene name higB Uniprot ID A0A0M4RY59
Locus tag FG172_RS17055 Protein ID WP_060420873.1
Coordinates 3510664..3510987 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0M5M3W3
Locus tag FG172_RS17050 Protein ID WP_060420390.1
Coordinates 3510330..3510626 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FG172_RS17030 3506627..3507742 + 1116 WP_100396967.1 glycosyltransferase family 9 protein -
FG172_RS17035 3507666..3508889 - 1224 WP_060439553.1 O-antigen ligase family protein -
FG172_RS17040 3508867..3509775 - 909 WP_060420392.1 hypothetical protein -
FG172_RS17045 3510080..3510322 + 243 WP_025303447.1 hypothetical protein -
FG172_RS17050 3510330..3510626 - 297 WP_060420390.1 helix-turn-helix domain-containing protein Antitoxin
FG172_RS17055 3510664..3510987 - 324 WP_060420873.1 toxin HigB-2 Toxin
FG172_RS17060 3511052..3511681 - 630 WP_141960693.1 alanyl-tRNA editing protein -
FG172_RS17065 3511767..3512702 + 936 WP_060439549.1 LysR family transcriptional regulator -
FG172_RS17070 3512685..3513332 - 648 WP_019452474.1 DNA oxidative demethylase AlkB -
FG172_RS17075 3513472..3514350 + 879 WP_049273981.1 EamA family transporter RarD -
FG172_RS17080 3514352..3515110 - 759 WP_072271000.1 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(45-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-83)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12370.15 Da        Isoelectric Point: 8.8132

>T127692 WP_060420873.1 NZ_CP041130:c3510987-3510664 [Serratia marcescens]
MDYLEFIETTVFSRKRAELMKDDDFQAFQSYLLLNHHEGDTISHTGGCKKIRWGLDGKGKRGGVRVIYYLTAPSGRVYLL
LIYRKNEKDDLSGQEKAILRSIVQQLD

Download         Length: 324 bp

>T127692 NZ_CP041130:c3510987-3510664 [Serratia marcescens]
ATGGACTATCTGGAGTTTATCGAAACGACCGTTTTCAGCCGAAAGCGGGCTGAATTGATGAAGGATGATGACTTTCAGGC
TTTCCAAAGCTATTTGCTGTTGAACCATCATGAAGGGGATACGATCAGCCACACGGGCGGATGCAAAAAGATACGCTGGG
GGCTGGACGGAAAGGGAAAACGCGGCGGCGTAAGAGTGATTTATTATCTGACGGCGCCCAGCGGCCGAGTCTATTTATTG
TTGATATACCGTAAAAATGAAAAGGATGATTTATCCGGGCAGGAAAAGGCGATATTGAGATCCATCGTTCAACAACTTGA
TTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11003.00 Da        Isoelectric Point: 10.1906

>AT127692 WP_060420390.1 NZ_CP041130:c3510626-3510330 [Serratia marcescens]
MKKELFDDLVSSMNEMVAIEKGKMTPKSEHVHRHAIPDVKLLRKSRGMKQAEFAKAVGASVGLVQSWEQERRIPSGSALK
LLLLIERNPALLDELLVI

Download         Length: 297 bp

>AT127692 NZ_CP041130:c3510626-3510330 [Serratia marcescens]
ATGAAAAAAGAACTTTTCGACGATTTGGTCAGCAGTATGAACGAAATGGTGGCGATCGAAAAGGGTAAGATGACGCCAAA
ATCCGAGCATGTTCACCGTCATGCTATTCCAGACGTCAAGCTGCTGCGCAAATCCCGTGGGATGAAGCAGGCGGAGTTTG
CCAAGGCTGTGGGGGCCAGCGTGGGACTGGTGCAAAGCTGGGAGCAGGAACGCCGCATACCCTCGGGGTCGGCACTGAAA
CTTCTGCTGCTTATTGAGCGTAACCCGGCATTGCTCGATGAGTTGCTGGTGATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M4RY59

Antitoxin

Source ID Structure
AlphaFold DB A0A0M5M3W3

References