Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 3476190..3476847 Replicon chromosome
Accession NZ_CP041123
Organism Serratia marcescens strain WVU-002

Toxin (Protein)


Gene name higB Uniprot ID A0A0M4RY59
Locus tag FBF86_RS16830 Protein ID WP_060420873.1
Coordinates 3476524..3476847 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0M5M3W3
Locus tag FBF86_RS16825 Protein ID WP_060420390.1
Coordinates 3476190..3476486 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FBF86_RS16805 3472487..3473602 + 1116 WP_100396967.1 glycosyltransferase family 9 protein -
FBF86_RS16810 3473526..3474749 - 1224 WP_060439553.1 O-antigen ligase family protein -
FBF86_RS16815 3474727..3475635 - 909 WP_060420392.1 hypothetical protein -
FBF86_RS16820 3475940..3476182 + 243 WP_025303447.1 hypothetical protein -
FBF86_RS16825 3476190..3476486 - 297 WP_060420390.1 helix-turn-helix domain-containing protein Antitoxin
FBF86_RS16830 3476524..3476847 - 324 WP_060420873.1 toxin HigB-2 Toxin
FBF86_RS16835 3476912..3477541 - 630 WP_141960693.1 alanyl-tRNA editing protein -
FBF86_RS16840 3477627..3478562 + 936 WP_060439549.1 LysR family transcriptional regulator -
FBF86_RS16845 3478545..3479192 - 648 WP_019452474.1 DNA oxidative demethylase AlkB -
FBF86_RS16850 3479332..3480210 + 879 WP_049273981.1 EamA family transporter RarD -
FBF86_RS16855 3480212..3480970 - 759 WP_072271000.1 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(45-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-83)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12370.15 Da        Isoelectric Point: 8.8132

>T127646 WP_060420873.1 NZ_CP041123:c3476847-3476524 [Serratia marcescens]
MDYLEFIETTVFSRKRAELMKDDDFQAFQSYLLLNHHEGDTISHTGGCKKIRWGLDGKGKRGGVRVIYYLTAPSGRVYLL
LIYRKNEKDDLSGQEKAILRSIVQQLD

Download         Length: 324 bp

>T127646 NZ_CP041123:c3476847-3476524 [Serratia marcescens]
ATGGACTATCTGGAGTTTATCGAAACGACCGTTTTCAGCCGAAAGCGGGCTGAATTGATGAAGGATGATGACTTTCAGGC
TTTCCAAAGCTATTTGCTGTTGAACCATCATGAAGGGGATACGATCAGCCACACGGGCGGATGCAAAAAGATACGCTGGG
GGCTGGACGGAAAGGGAAAACGCGGCGGCGTAAGAGTGATTTATTATCTGACGGCGCCCAGCGGCCGAGTCTATTTATTG
TTGATATACCGTAAAAATGAAAAGGATGATTTATCCGGGCAGGAAAAGGCGATATTGAGATCCATCGTTCAACAACTTGA
TTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11003.00 Da        Isoelectric Point: 10.1906

>AT127646 WP_060420390.1 NZ_CP041123:c3476486-3476190 [Serratia marcescens]
MKKELFDDLVSSMNEMVAIEKGKMTPKSEHVHRHAIPDVKLLRKSRGMKQAEFAKAVGASVGLVQSWEQERRIPSGSALK
LLLLIERNPALLDELLVI

Download         Length: 297 bp

>AT127646 NZ_CP041123:c3476486-3476190 [Serratia marcescens]
ATGAAAAAAGAACTTTTCGACGATTTGGTCAGCAGTATGAACGAAATGGTGGCGATCGAAAAGGGTAAGATGACGCCAAA
ATCCGAGCATGTTCACCGTCATGCTATTCCAGACGTCAAGCTGCTGCGCAAATCCCGTGGGATGAAGCAGGCGGAGTTTG
CCAAGGCTGTGGGGGCCAGCGTGGGACTGGTGCAAAGCTGGGAGCAGGAACGCCGCATACCCTCGGGGTCGGCACTGAAA
CTTCTGCTGCTTATTGAGCGTAACCCGGCATTGCTCGATGAGTTGCTGGTGATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M4RY59

Antitoxin

Source ID Structure
AlphaFold DB A0A0M5M3W3

References