Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 13609..14266 | Replicon | plasmid unnamed4 |
| Accession | NZ_CP041103 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain KPCTRSRTH07 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | CI661_RS28395 | Protein ID | WP_000270043.1 |
| Coordinates | 13916..14266 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | CI661_RS28390 | Protein ID | WP_000124640.1 |
| Coordinates | 13609..13911 (-) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CI661_RS28340 | 9234..9662 | + | 429 | WP_000591074.1 | hypothetical protein | - |
| CI661_RS28345 | 9719..10078 | + | 360 | WP_000422768.1 | hypothetical protein | - |
| CI661_RS28350 | 10078..10524 | + | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| CI661_RS28355 | 10521..11039 | + | 519 | WP_000210756.1 | nitrite reductase | - |
| CI661_RS28360 | 11039..11269 | + | 231 | WP_000972663.1 | hypothetical protein | - |
| CI661_RS28365 | 11256..12113 | + | 858 | WP_001167032.1 | hypothetical protein | - |
| CI661_RS28375 | 12344..12871 | + | 528 | WP_001236377.1 | thermonuclease family protein | - |
| CI661_RS28380 | 12929..13201 | + | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| CI661_RS28385 | 13289..13582 | + | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| CI661_RS28390 | 13609..13911 | - | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| CI661_RS28395 | 13916..14266 | - | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| CI661_RS28400 | 14429..14977 | + | 549 | WP_001061574.1 | transcriptional regulator | - |
| CI661_RS28410 | 15318..15512 | + | 195 | WP_000343597.1 | hypothetical protein | - |
| CI661_RS28415 | 15523..15894 | + | 372 | WP_000516916.1 | hypothetical protein | - |
| CI661_RS28420 | 15887..16294 | + | 408 | Protein_26 | hypothetical protein | - |
| CI661_RS28425 | 16285..16524 | + | 240 | Protein_27 | helix-turn-helix domain-containing protein | - |
| CI661_RS28430 | 16521..16745 | + | 225 | WP_000743213.1 | hypothetical protein | - |
| CI661_RS28435 | 16956..18449 | + | 1494 | WP_001120888.1 | IS91-like element ISVsa3 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..82819 | 82819 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 17237.68 Da Isoelectric Point: 5.5500
>T127594 WP_000270043.1 NZ_CP041103:c14266-13916 [Klebsiella pneumoniae subsp. pneumoniae]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
Download Length: 351 bp
>T127594 NZ_CP041103:c14266-13916 [Klebsiella pneumoniae subsp. pneumoniae]
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Antitoxin
Download Length: 101 a.a. Molecular weight: 14882.85 Da Isoelectric Point: 5.5500
>AT127594 WP_000124640.1 NZ_CP041103:c13911-13609 [Klebsiella pneumoniae subsp. pneumoniae]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFF
Download Length: 303 bp
>AT127594 NZ_CP041103:c13911-13609 [Klebsiella pneumoniae subsp. pneumoniae]
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Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|