Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 321732..322318 Replicon chromosome
Accession NZ_CP041092
Organism Klebsiella pneumoniae subsp. pneumoniae strain KPCTRSRTH01

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag CI667_RS01510 Protein ID WP_094488152.1
Coordinates 321950..322318 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag CI667_RS01505 Protein ID WP_004174006.1
Coordinates 321732..321953 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CI667_RS01485 317889..318815 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
CI667_RS01490 318812..320089 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
CI667_RS01495 320086..320853 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
CI667_RS01500 320855..321568 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
CI667_RS01505 321732..321953 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CI667_RS01510 321950..322318 + 369 WP_094488152.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
CI667_RS01515 322591..323907 + 1317 WP_094488153.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
CI667_RS01520 324014..324901 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
CI667_RS01525 324898..325743 + 846 WP_004185988.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
CI667_RS01530 325745..326815 + 1071 WP_094488154.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 318812..327552 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(24-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13567.90 Da        Isoelectric Point: 8.6410

>T127571 WP_094488152.1 NZ_CP041092:321950-322318 [Klebsiella pneumoniae subsp. pneumoniae]
MTLQIISAEEIIQFHDRQLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T127571 NZ_CP041092:321950-322318 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCAGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT127571 WP_004174006.1 NZ_CP041092:321732-321953 [Klebsiella pneumoniae subsp. pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT127571 NZ_CP041092:321732-321953 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References