Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 4009022..4009619 Replicon chromosome
Accession NZ_CP041082
Organism Klebsiella pneumoniae strain Kp202

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag FJV42_RS19830 Protein ID WP_004142563.1
Coordinates 4009302..4009619 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag FJV42_RS19825 Protein ID WP_004142561.1
Coordinates 4009022..4009309 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FJV42_RS19795 4005103..4005351 + 249 WP_002893037.1 DUF1158 domain-containing protein -
FJV42_RS19800 4005369..4005710 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
FJV42_RS19805 4005741..4006856 - 1116 Protein_3858 MBL fold metallo-hydrolase -
FJV42_RS19810 4007035..4007616 + 582 WP_032419262.1 TetR/AcrR family transcriptional regulator -
FJV42_RS19815 4007616..4007984 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
FJV42_RS19820 4008104..4008757 + 654 WP_032419263.1 oxygen-insensitive NAD(P)H nitroreductase -
FJV42_RS19825 4009022..4009309 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
FJV42_RS19830 4009302..4009619 - 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FJV42_RS19835 4009804..4010847 - 1044 WP_032419264.1 DUF2157 domain-containing protein -
FJV42_RS19845 4011514..4012380 - 867 WP_032419265.1 helix-turn-helix transcriptional regulator -
FJV42_RS19850 4012489..4013916 + 1428 WP_004176980.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T127558 WP_004142563.1 NZ_CP041082:c4009619-4009302 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T127558 NZ_CP041082:c4009619-4009302 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT127558 WP_004142561.1 NZ_CP041082:c4009309-4009022 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT127558 NZ_CP041082:c4009309-4009022 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACAGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References