Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4885373..4886021 Replicon chromosome
Accession NZ_CP041051
Organism Citrobacter sp. CF971

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag E6P06_RS27180 Protein ID WP_049000674.1
Coordinates 4885659..4886021 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E6P06_RS27175 Protein ID WP_049000676.1
Coordinates 4885373..4885672 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E6P06_RS27155 4881694..4882110 - 417 WP_003023951.1 GNAT family N-acetyltransferase -
E6P06_RS27160 4882241..4882534 + 294 WP_003840665.1 hypothetical protein -
E6P06_RS27165 4882629..4884011 + 1383 WP_139935879.1 glycoside hydrolase family 1 protein -
E6P06_RS27170 4884061..4885254 - 1194 WP_003840662.1 purine ribonucleoside efflux pump NepI -
E6P06_RS27175 4885373..4885672 - 300 WP_049000676.1 helix-turn-helix transcriptional regulator Antitoxin
E6P06_RS27180 4885659..4886021 - 363 WP_049000674.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E6P06_RS27185 4886122..4886574 - 453 WP_003023933.1 DUF1198 family protein -
E6P06_RS27190 4886700..4888091 - 1392 WP_139935880.1 hexose-6-phosphate:phosphate antiporter -
E6P06_RS27195 4888234..4889562 - 1329 WP_057101854.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-88)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13716.59 Da        Isoelectric Point: 5.6550

>T127530 WP_049000674.1 NZ_CP041051:c4886021-4885659 [Citrobacter sp. CF971]
MWEVETTDAFDKWFDVQTEALKEDMLAAMMILSEYGPQLGRPFADTVNASAFSNMKGLRVQHQGSPIRAFFAFDPSRHGI
VLCAGDKTGLNEKKFYKEMIRLADAEYRNHLISKENYGYP

Download         Length: 363 bp

>T127530 NZ_CP041051:c4886021-4885659 [Citrobacter sp. CF971]
ATGTGGGAAGTGGAAACAACGGATGCTTTCGATAAATGGTTTGACGTACAGACCGAAGCGCTCAAGGAAGATATGCTCGC
AGCAATGATGATTTTATCCGAGTATGGTCCTCAGTTAGGTAGGCCGTTTGCTGATACGGTAAATGCTTCTGCTTTTTCAA
ATATGAAAGGGTTGCGAGTACAGCATCAGGGTAGTCCGATTCGGGCGTTCTTCGCGTTTGATCCTTCTCGCCATGGCATC
GTGCTATGCGCTGGAGATAAAACAGGGTTAAACGAAAAGAAATTCTATAAAGAGATGATCAGGCTTGCGGATGCTGAGTA
CCGAAATCACCTAATAAGTAAGGAAAATTATGGCTACCCTTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10990.81 Da        Isoelectric Point: 8.5047

>AT127530 WP_049000676.1 NZ_CP041051:c4885672-4885373 [Citrobacter sp. CF971]
MATLKELMAKQSAESQERITEKVEILRQAVALNMLREELNLSQAELASAMGVKQPTIAKMEQADNDPRLSTLKRYVTALG
GELSIDVKLPTGKRVAFYL

Download         Length: 300 bp

>AT127530 NZ_CP041051:c4885672-4885373 [Citrobacter sp. CF971]
ATGGCTACCCTTAAAGAATTGATGGCGAAACAAAGCGCGGAAAGCCAGGAGCGTATTACCGAAAAAGTAGAAATACTACG
TCAGGCGGTTGCGTTAAATATGTTAAGGGAAGAACTGAATCTCTCTCAGGCTGAACTTGCCTCGGCAATGGGTGTTAAGC
AGCCAACAATCGCAAAAATGGAGCAGGCAGATAACGATCCTCGTCTGTCGACGCTCAAGCGTTATGTCACGGCACTGGGT
GGTGAACTTAGCATTGATGTTAAGCTACCTACAGGTAAAAGAGTCGCGTTCTATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References