Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 2447226..2447788 | Replicon | chromosome |
Accession | NZ_CP041051 | ||
Organism | Citrobacter sp. CF971 |
Toxin (Protein)
Gene name | higB | Uniprot ID | A0A8B5QCT4 |
Locus tag | E6P06_RS15255 | Protein ID | WP_003836234.1 |
Coordinates | 2447226..2447504 (+) | Length | 93 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | A0A8B5QC60 |
Locus tag | E6P06_RS15260 | Protein ID | WP_003836231.1 |
Coordinates | 2447504..2447788 (+) | Length | 95 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
E6P06_RS15235 | 2442304..2442735 | - | 432 | WP_003020036.1 | peroxiredoxin OsmC | - |
E6P06_RS15240 | 2442963..2443103 | + | 141 | WP_003020039.1 | stationary-phase-induced ribosome-associated protein | - |
E6P06_RS15245 | 2443283..2444980 | + | 1698 | WP_003836239.1 | malate dehydrogenase | - |
E6P06_RS15250 | 2445290..2447005 | + | 1716 | WP_139935416.1 | ATP-binding cassette domain-containing protein | - |
E6P06_RS15255 | 2447226..2447504 | + | 279 | WP_003836234.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
E6P06_RS15260 | 2447504..2447788 | + | 285 | WP_003836231.1 | HigA family addiction module antidote protein | Antitoxin |
E6P06_RS15265 | 2447832..2448434 | - | 603 | WP_003843693.1 | inorganic diphosphatase | - |
E6P06_RS15270 | 2448564..2449220 | - | 657 | WP_003020054.1 | formate dehydrogenase-N subunit gamma | - |
E6P06_RS15275 | 2449213..2450097 | - | 885 | WP_003833024.1 | formate dehydrogenase N subunit beta | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10637.28 Da Isoelectric Point: 9.8965
>T127518 WP_003836234.1 NZ_CP041051:2447226-2447504 [Citrobacter sp. CF971]
MIMNFRHKGLRDLFLHGRTSGVMAKHVRRLRHRLAVIDAASKVTDINMPGYKLHPLVGDRDGIWAIAVSGNWRITFEFVN
GDAYILDYEDYH
MIMNFRHKGLRDLFLHGRTSGVMAKHVRRLRHRLAVIDAASKVTDINMPGYKLHPLVGDRDGIWAIAVSGNWRITFEFVN
GDAYILDYEDYH
Download Length: 279 bp
>T127518 NZ_CP041051:2447226-2447504 [Citrobacter sp. CF971]
ATGATCATGAACTTCAGACACAAGGGATTGCGAGATTTGTTTCTTCATGGAAGAACATCAGGCGTTATGGCGAAACATGT
CCGACGATTACGACACAGGCTTGCCGTTATTGATGCGGCAAGCAAGGTTACAGATATCAATATGCCCGGTTATAAGCTAC
ATCCTCTGGTAGGTGATCGTGATGGCATATGGGCAATAGCTGTTTCAGGTAACTGGCGTATTACGTTTGAATTCGTCAAT
GGCGACGCGTACATACTGGACTACGAGGACTATCATTGA
ATGATCATGAACTTCAGACACAAGGGATTGCGAGATTTGTTTCTTCATGGAAGAACATCAGGCGTTATGGCGAAACATGT
CCGACGATTACGACACAGGCTTGCCGTTATTGATGCGGCAAGCAAGGTTACAGATATCAATATGCCCGGTTATAAGCTAC
ATCCTCTGGTAGGTGATCGTGATGGCATATGGGCAATAGCTGTTTCAGGTAACTGGCGTATTACGTTTGAATTCGTCAAT
GGCGACGCGTACATACTGGACTACGAGGACTATCATTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10358.10 Da Isoelectric Point: 8.8094
>AT127518 WP_003836231.1 NZ_CP041051:2447504-2447788 [Citrobacter sp. CF971]
MKMANHPRPGDIIQEALEELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPEMWLNLQTTWSLAEAQ
KSVDISRLRKLAVQ
MKMANHPRPGDIIQEALEELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPEMWLNLQTTWSLAEAQ
KSVDISRLRKLAVQ
Download Length: 285 bp
>AT127518 NZ_CP041051:2447504-2447788 [Citrobacter sp. CF971]
ATGAAGATGGCAAATCATCCCCGTCCTGGGGATATCATTCAGGAAGCGCTGGAAGAACTCAATGTCAGCCTGCGCGAGTT
TGCCAGAGCTATGGAGATTGCACCTTCAACGGCAAGTCGACTATTAACCGGGAAAGCAGCCCTAACGCCTGAGATGGCGA
TTAAACTCTCTGTAGTGATTGGCAGCTCACCCGAAATGTGGTTAAACCTGCAAACTACCTGGAGTCTGGCAGAAGCCCAA
AAAAGCGTGGATATTTCACGCCTGCGTAAGCTGGCAGTACAGTGA
ATGAAGATGGCAAATCATCCCCGTCCTGGGGATATCATTCAGGAAGCGCTGGAAGAACTCAATGTCAGCCTGCGCGAGTT
TGCCAGAGCTATGGAGATTGCACCTTCAACGGCAAGTCGACTATTAACCGGGAAAGCAGCCCTAACGCCTGAGATGGCGA
TTAAACTCTCTGTAGTGATTGGCAGCTCACCCGAAATGTGGTTAAACCTGCAAACTACCTGGAGTCTGGCAGAAGCCCAA
AAAAGCGTGGATATTTCACGCCTGCGTAAGCTGGCAGTACAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A8B5QCT4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A8B5QC60 |