Detailed information of TA system TA127494

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 796709..797047
• Replicon: chromosome
• Accession: NZ_CP041037
• Organism: Staphylococcus aureus strain NP66

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: FIV54_RS04015
• Protein ID: WP_011447039.1
• Coordinates: 796709..796885 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	796873..797047 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FIV54_RS03995	794396..794548	+	153	WP_000654329.1	hypothetical protein	-
FIV54_RS04000	794595..794882	+	288	WP_001040255.1	hypothetical protein	-
FIV54_RS04005	794938..795312	+	375	WP_000340977.1	hypothetical protein	-
FIV54_RS04010	795733..796506	+	774	WP_025174055.1	staphylococcal enterotoxin type P	-
FIV54_RS04015	796709..796885	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	796873..797047	-	175	-	-	Antitoxin
FIV54_RS04025	797097..797351	+	255	WP_000611512.1	phage holin	-
FIV54_RS04030	797363..798118	+	756	WP_000861038.1	CHAP domain-containing protein	-
FIV54_RS04035	798309..798800	+	492	WP_000920038.1	staphylokinase	-
FIV54_RS04055	799451..799786	+	336	Protein_771	SH3 domain-containing protein	-
FIV54_RS04060	800296..800646	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
FIV54_RS04065	800699..800959	-	261	WP_001791826.1	hypothetical protein	-
FIV54_RS04075	801270..801449	-	180	WP_000669791.1	hypothetical protein	-
FIV54_RS04080	801771..802021	-	251	Protein_775	sphingomyelin phosphodiesterase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlb / see / sak / scn / hlb / map	778957..804155	25198

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T127494 WP_011447039.1 NZ_CP041037:796709-796885 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T127494 NZ_CP041037:796709-796885 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT127494 NZ_CP041037:c797047-796873 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin