Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 397191..397708 Replicon chromosome
Accession NZ_CP041037
Organism Staphylococcus aureus strain NP66

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag FIV54_RS01930 Protein ID WP_000113262.1
Coordinates 397442..397708 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag FIV54_RS01925 Protein ID WP_000584499.1
Coordinates 397191..397442 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIV54_RS01895 392889..393608 + 720 WP_000479576.1 amino acid ABC transporter permease -
FIV54_RS01900 393605..394336 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
FIV54_RS01905 394433..395683 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
FIV54_RS01910 395938..396300 + 363 WP_000819843.1 DUF4467 domain-containing protein -
FIV54_RS01915 396319..396918 + 600 WP_000162810.1 DsbA family protein -
FIV54_RS01920 396925..397026 + 102 Protein_370 hypothetical protein -
FIV54_RS01925 397191..397442 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FIV54_RS01930 397442..397708 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
FIV54_RS01935 398002..399552 + 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
FIV54_RS01940 399738..400205 + 468 WP_000153344.1 SRPBCC domain-containing protein -
FIV54_RS01945 400292..400474 + 183 WP_000079142.1 hypothetical protein -
FIV54_RS01950 400691..401515 + 825 WP_000572040.1 formate/nitrite transporter family protein -
FIV54_RS01955 401749..402285 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T127487 WP_000113262.1 NZ_CP041037:397442-397708 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T127487 NZ_CP041037:397442-397708 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT127487 WP_000584499.1 NZ_CP041037:397191-397442 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT127487 NZ_CP041037:397191-397442 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References