Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 371837..372021 Replicon chromosome
Accession NZ_CP041037
Organism Staphylococcus aureus strain NP66

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag FIV54_RS01790 Protein ID WP_000482647.1
Coordinates 371837..371944 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 371961..372021 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FIV54_RS01765 367204..367677 + 474 WP_000456489.1 GyrI-like domain-containing protein -
FIV54_RS01770 367800..369011 - 1212 WP_001191923.1 multidrug effflux MFS transporter -
FIV54_RS01775 369193..369852 - 660 WP_000831298.1 membrane protein -
FIV54_RS01780 369912..371054 - 1143 WP_001176863.1 glycerate kinase -
FIV54_RS01785 371312..371698 + 387 WP_000779347.1 flippase GtxA -
FIV54_RS01790 371837..371944 + 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
- 371961..372021 - 61 - - Antitoxin
FIV54_RS01795 372648..374411 + 1764 WP_001064816.1 ABC transporter ATP-binding protein/permease -
FIV54_RS01800 374436..376169 + 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
FIV54_RS01805 376398..376565 + 168 Protein_348 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T127485 WP_000482647.1 NZ_CP041037:371837-371944 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T127485 NZ_CP041037:371837-371944 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT127485 NZ_CP041037:c372021-371961 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References